Thiazolidinedione

Question 1

Main drugs (and class nickname)

Answer 1

Nickname: “glitazones”

Pioglitazone (Actos)

Question 2

MOA

Answer 2

1) Increase uptake of glucose in peripheral tissues

2) Decrease hepatic gluconeogenesis

Question 3

Contrainidications

Answer 3

New York Heart Association class III and IV cardiac status
Active disease of liver

Question 4

Serious adverse effects

Answer 4

Edema (3-4% monotherapy and 10-15% in conjunction w/insulin) –> which may lead to HF
Increased fracture risk (1.9 per 100 pt-years) in women
Anemia (4%)
Bladder cancer (only after long-term use)

Question 5

Common adverse effects

Answer 5

Weight gain