GLP-1 Receptor Analogs

Question 1

Common drugs

Answer 1

Exenatide (Byetta) - SC BID

Liraglutide (Victoza) - SC q week

Question 2

MOA

Answer 2

Increasing insulin secretion
Decreasing glucagon secretion
Delay gastric emptying

Question 3

Contraindications

Answer 3

Pancreatitis hx
Family hx of medullary thyroid CA (Victoza)
Decreased kidney function (Byetta)

Question 4

Serious adverse reactions

Answer 4

Pancreatitis (30 (Byetta) and 6 (Victoza) reports in patients mostly already at risk)
Nephrotoxicity (generally had pre-existing kidney disease or risk factors, may have been exacerbated by N/V/D (Byetta only)
Medullary thyroid cancer
MEN type 2
Hypoglycemia (w/SU)

Question 5

Common adverse reactions

Answer 5

Nausea (40% - Byetta, 10% - Victoza) - dose related and transient
Delays gastric emptying - abx and OCPs should be taken 1 hour before