Biguanides Flashcards
1
Q
Most common drugs
A
Metformin (Glucophage)
2
Q
MOA
A
1) Decrease hepatic gluconeogenesis
2) Increase insulin sensitivity
3) Increase peripheral glucose uptake
3
Q
Contraindications
A
Decreased kidney function
Decreased hepatic function
Temporarily for iodinated contrast agents
4
Q
Serious adverse reactions
A
Lactic acidosis (generally only in contraindicated patients)
5
Q
Common adverse reactions
A
Diarrhea (20%); other GI symptoms (anorexia, N/V, abdominal discomfort
Generally dose-related and transient
