Therapeutics

Question 1

Warfarin and NSAIDs

Answer 1

Enhanced bleeding

Question 2

Warfarin and ABx

Answer 2

Esp claryithromycin and ciprofloxacin - enhanced bleeding

Question 3

NSAID and methotrexate

Answer 3

Methotrexate toxicity

Question 4

ACEi and K sparing diuretics

Answer 4

hyperkalaemia

Question 5

Verapamil and beta blockers

Answer 5

Asystole risk

Question 6

Digoxin and amiodarone

Answer 6

risk of digoxin toxicity

Question 7

Oral contraceptive and rifampicin

Answer 7

contraception failure

Question 8

oral contraceptive and carbamazepine

Answer 8

risk of contraception failure

Question 9

oral contraceptive and phenytoin

Answer 9

risk of failure of contraception

Question 10

statin and macrolides

Answer 10

risk of myopathy

Question 11

Dihydropyridines

Answer 11

CCB that act on vascular smooth muscle and cause peripheral arterial dilatation

Question 12

Non DHPs

Answer 12

E.g. verapamil and diltiazem.

Question 13

Verapamil

Answer 13

Selective for the heart. NDHP. Negative ionotrope and chronotrope.
Used in HTN, angina and SVT

Question 14

Diltiazem

Answer 14

causes some peripheral and coronary arterial dilatation. Negative ionotrope and chronotrope (less so than verapamil).
Used in angina