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USMLE High Yield Flashcards > Therapeutic mAbs and cytokines > Flashcards

Therapeutic mAbs and cytokines Flashcards

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USMLE® Step 1 flashcards
1
Q

Basiliximab / Dacluzimab

A

Target: IL-2 receptor on T cells

Used in kidney transplant rejection prophylaxis

Side effects: Edema, hypertension, tremor

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2
Q

Bevacizumab

A

Target: VEGF

Used in colorectal cancer and renal cell carcinoma

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3
Q

Cetuximab

A

Target: EGFR

Used in stage IV colorectal cancer

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4
Q

Rituximab

A

Target: CD20 on B cells

Used in B-cell non-Hodgkin lymphomas, rheumatoid arthritis (along with MTX) and immune thrombocytopenia

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5
Q

Trastuzumab

A

Target: HER2/neu receptor

Used in HER2+ breast cancer

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6
Q

Infliximab / Adalimumab

A

Target: TNF-alpha

Used in inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis, and psoriasis

*Always do PPD test first; anti-TNF activity can re-activate latent TB

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7
Q

Abciximab

A

Target: Glycoprotein IIb/IIIa on platelets

Used as anti-platelet therapy for patients undergoing percutaneous coronary intervention

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8
Q

Denosumab

A

Target: RANKL

Used in osteoporosis; inhibits osteoclast maturation

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9
Q

Omalizumab

A

Target: IgE

Used in allergic asthma

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10
Q

Palivizumab

A

Target: RSV F protein

Used as RSV prophylaxis in high-risk infants

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11
Q

Natalizumab

A

Target: alpha4-integrin (involved in leukocyte adhesion)

Used in Multiple Sclerosis and Crohn’s Disease

*Risk of PML in patients with JC virus

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12
Q

Epoetin alfa (erythropoietin)

A

Used to treat anemias, especially in renal failure

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13
Q

Thrombopoietin

A

Used to treat thrombocytopenia

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14
Q

Oprelvekin (interleukin-11)

A

Used to treat thrombocytopenia

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15
Q

Filgrastim

A

AKA granulocyte colony-stimulating factor (G-CSF)

Recovery of bone marrow

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16
Q

Sargramostim

A

AKA granulocyte/macrophage colony-stimulating factor

Recovery of bone marrow

17
Q

Aldesleukin (IL-2)

A

Renal cell carcinoma, metastatic melanoma

18
Q

IFN-alpha

A 
Chronic hepatitis B and C 
Kaposi sarcoma 
Hairy cell leukemia
Condyloma acuminatum
Renal cell carcinoma 
Malignant melanoma
19
Q

IFN-beta

A

Multiple Sclerosis

20
Q

IFN-y

A

Chronic granulomatous disease

USMLE High Yield Flashcards (17 decks)

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