Pathoma Carcinogenesis I Flashcards
Carcinogens
Damage DNA
Aflatoxins (from aspergillus - stored rice, grains)
Hepatocellular Carcinoma
Alkylating Agents
Leukemia/Lymphoma
Alcohol
SCC of oropharynx, upper esophagous, HCC Pancreatic carcinoma
Arsenic
SCC skin (old timer women-put on skin) Lung cancer (cigarette smoke)
Asbestos
Lung carcinoma (more likely) Mesothelioma
Cigarette smoke (Polycyclic hydrocarbons***)
Carcinoma of Oropharynx Carcinoma of Lung Carcinoma of Kidney Carcinoma of Bladder Carcinoma of Pancreas
Nitrosamines
Stomach carcinoma (Japan-smoked foods) (Intestinal type)
Naphthylamine (Cigarette smoke**)
Urothelial carcinoma of the bladder
Vinyl chloride (PVC)
Angiocarcinoma of the liver
Nickel, Chromium, Beryllium, Silica (occupational exposure)
Lung carcinoma
EBV
Nasopharygeal carcinoma Burkitt lymphoma CNS lymphoma (AIDS)
Nasopharygeal carcinoma Cx
Chinese Male, African male Neck mass
HHV-8
Kaposi Sarcoma (tumor of endothelial cells)
Who gets Kaposi sarcoma?
Eastern European males (excise) AIDS patients (treat HIV) Transplants (reduce immunosupression)
HBV, HCV (DNA, RNA)
Hepatocellular carcinoma
HTLV-1
Adult T-cell leukemia/lymphoma
HPV (16, 18)
SCC vulva, vagina, anus, cervix, adenocarcinoma of the cervix
Ionizing radiation (nuclear accident)
AML CML Papillary carcinoma of the thyroid
Ionizing radiation mechanism
via hydroxyl free radicals
Nonionizing radiation (UVB)
Basal cell carcinoma SCC Melanoma of the skin
Nonionizing radiation mechanism
Pyrimidine dimers in DNA Excised by restriction endonuclease
Disease where restriciton endonucleases are non-functioning, leads to high likelihood of skin cancer?
Xeroderma Pigmentosum
