Therapeutic Hormones Flashcards
What is GH?
Human growth hormone
What is FSH?
Follicle Stimulating Hormone
Where are GH and FSH secreted from?
Anterior Pituitary Gland
What hormones are the gonadotropins?
FSH and LH
Where does GH act?
Muscle and Bones
Where do the gonadotropins act?
Testes and Ovaries
What is is endogenous GH known as?
Somatotropin
What are the 2 routes by which GH acts by?
Direct effect - due to GH binding to its receptor on target cells
Indirect effect - stimulates liver to produce IGF-1
What is IGF-1?
Insulin-like growth factor 1
What is the effect of GH on soft tissue and bones?
Promotes growth of soft tissue by increasing cell size and number
Causes bones to growth in terms of length and thickness
Action on bones and tissue is mainly indirect (IGF-1)
What is the effect of GH on metabolism? (Protein, Fat & Glucose)
Increases amino acid uptake
Increased protein synthesis
Inhibits protein degradation
Increased blood fatty acid levels (triglyceride break down)
Increased blood glucose levels (decreases glucose uptake by muscles and increasing glucose output of liver)
List the other effects of hGH
Stimulate immune response
Increase glomerular filtration rate
Influence release of insulin, glucagon & thyroid hormones
True or false : All treatment with human growth hormone is via the recombinant method
True
What is the difference between recombinant GH (E.Coli) and endogenous GH?
Recombinant GH has an N-terminal Methionine residue
What are the clinical uses for recombinant GH?
- Promote linear growth in children with GH deficiency
- Modulation of metabolism in adults
- hGH deficiency
- short bowel syndrome
- Wasting disease in aids
