Nasal Vaccine Delivery

Question 1

List the advantages of nasal vaccine delivery

Answer 1

Skin barrier is not compromised
Generates a humoral and cell-mediated response
Avoids pH, bile salts and proteases (as with oral route)
Good responses in distant sites (intestines, lungs)
Only small doses required
Easy access

Question 2

List the disadvantages of nasal vaccine delivery

Answer 2

Small doses are required as large doses may be swallowed
Issues with developing in animal models

Question 3

How do formulation factors affect nasal vaccine delivery?

Answer 3

Encapsulation in a microsphere has increased response

Transforming a soluble vaccine to a particulate increases uptake

Question 4

Name an example of a nasal vaccine delivery system

Answer 4

Flumist
A live attenuated nasal flu vaccine