theophylline Flashcards
what is the classification of theophylline
xanthine derivatives (bronchodilator)
what is the trade name for theophylline
Slo-phyllin
what is the pharmacotherapeutic (use) of theophylline
indicated for the symptomatic relief or prevention of bronchial asthma and reversal of bronchospasm associated with CAL
how is theophylline administered
orally or IV
what is the peak of theophylline
2 hours
what is the pharmacodynamics of theophylline
it is believed that bronchodilation is caused by inhibition of phophodiesterase
what is the C/I and precautions of theophylline
hypersensitivity, status asthmaticus, or peptic ulcer because of the excitatory and stimulatory effect of the medication
what are the A/E of theophylline
related directly to serum levels of the drug. may cause GI effects such as loss of appetite, hematemesis (vomiting blood), gastro-esophageal reflux
what are the drug interactions of theophylline
multiple drug interactions
what health status would you assess with a pt taking theophylline
assess for C/I to therapy
what life span and gender would you assess with a pt taking theophylline
assess pregnancy and lactation status
what life style, diet, and habit would you assess with a pt taking theophylline
- assess if pt smokes, as it may cause increased vascoconstriction
- assess older men for possible prostate enlargement due to increased metabolic influences of drug
what environment would you assess with a pt taking theophylline
IV formulation given in acute care setting
how would you maximize the therapeutic effects of theophylline
in the hospital setting, administer theophylline at a rate of not more than 25 mg/minute
how would you minimize the A/E of theophylline
- monitor serum theophylline levels carefully and discuss dosage adjustment
- administer immediate-release preparations with a meal to decrease GI distress
- administer sustained-release preparation 1 hour before, or 2 hours after meals
