Theme C lecture 3 Flashcards
1
Q
What is the different phenotype seen in adults who are born small?
A
Number of nephron is less in adults born small.
Changes in sodium channels (mutations in sodium channels or number of sodium channels)
Changes in GFR
Altered RAS and apoptotic genes
2
Q
When does nephrogenesis occur?
A
Nephrogenesis starts early in development. in humans.
3
Q
What is cross-fostering?
A
Cross-fostering is the technique by which mice born to a stressed mother are suckled by another mother
4
Q
Why do adults who are born small have problems with hypertension?
A
Adults born small have higher levels of plasma renin.
Smaller kidneys
Lower nephron number
Altered ANG2 receptor expression
Altered renal function
Hypertension
Less nephrons
Less glomeruli
