The sustained increase

Question 1

The sustained increase in arterial pressure therefore

Answer 1

can be related to elevation of pulmonary vascular resistance as a combination of these two hypoxia-induced mechanisms

Question 2

In most healthy individuals

Answer 2

this moderate increase in mean PAP is asymptomatic and once stabilised is well tolerated

Question 3

However the pulmonary response to hypoxia between healthy people

Answer 3

varies significantly with certain individuals susceptible to subacute mountain sickness (SMS)

Question 4

Obliterative vascular remodelling can occur in approx.

Answer 4

1-5% of native sea population that travel to high altitude characterised by aggressive remodellin and an occluded lumen

Question 5

In this circumstance, a progressive increase in pulmonary vascular resistance and thus increased arterial pressure

Answer 5

can frequently lead to right heart failure and death

Question 6

Demonstrating that in some individuals alveolar hypoxia

Answer 6

can cause life-threatening pulmonary hypertension in previously healthy lungs

Question 7

In those with SMS

Answer 7

return to sea level can reverse fatal effects

Question 8

Interestingly, these observations in healthy individuals at high alt allow for study of

Answer 8

integrated hypoxic responses in absence of disease factors, where altitude-induced hypoxemia produces the same effects as hypoxaemia of other causes

Question 9

It is possible therefore to relate the mechanisms involved in…

Answer 9

sustained increase in arterial pressure to pulmonary hypertension observed in chronic hypoxic lung diseases