In conclusion

Question 1

The sustained increase in PAP observed at high altitude among healthy individuals

Answer 1

highlights relevance of mechanisms such as HPV and pulmonary vascular remodelling to the PH observed in chronic lung diseases such as COPD

Question 1

The parallels between high-altitude- induced PH and COPD-associated PH

Answer 1

driven by hypoxia offer valuable perspectives for potential therapeutics

Question 2

The relationship between hypoxia and PH suggests potential pharmacological interventions

Answer 2

targeting selective pulmonary vasodilatory pathways aiming to alleviate the increased PVR

Question 3

FM, the observation that sensitivity to hypoxia may vary among individuals suggests the intriguing possibility of epigenetic influence on

Answer 3

susceptibility to chronic hypoxic lung diseases

Question 4

understanding these factors may lead to advances in personalised medicine and

Answer 4

targeted interventions in at risk populations