As previously mentioned

Question 1

As previously mentioned, hypoxia itself can cause

Answer 1

severe PH with SMS occuring in a portion of otherwise healthy individuals that travel to high altitude

Question 2

However, the fact that majority of those that travel to high alt

Answer 2

do not experience these negative effects led to the hypothesis that within the normal sea-level population the sensitivity of the pulmonary circulation to hypoxia may vary between individuals

Question 3

It is argued therefore that if these individuals were to develop COPD that they may be at a higher risk

Answer 3

of right ventricular failure and increased mortaility

Question 4

This hypothesis suggests the role of epigenetic variability

Answer 4

being the effect of one’s environment on their genetics and how this may result in altered susceptibility to chronic hypoxic lung diseases such as COPD

Question 5

Another example of potential genetic variability in sea-level natives is

Answer 5

in cows brought to the rockies (>2500m) during summer where susceptible cattle are shown to develop PH resulting in RH failure, oedema (brisket) and death

Question 6

High alt pulmonary hypertension (HAPH) occurs in about

Answer 6

20% (10-50%) of the animals (Newman et al. 2011)