In the past

Question 1

In the past, structural changes to the vasculature were considered the dominant mechanism underlying HPH in healthy lungs

Answer 1

where sustained exposure to sea-level PO2 restored PAP to baseline in chronically hypoxic animal models due to regression of prior remodellinh

Question 2

However, these observations were primarily based on histological data

Answer 2

with fixed speciments not fully representative of structural features in living organisms

Question 3

In human sea level dwellers with stabilised HPH at high alt

Answer 3

acute normalisation of alveolar O2 did not substantially alter resistance instead small changes in PAP were attributed to reductions in cardiac output

Question 4

FM, adminstration of vasodilators such as prostacyclin were not shown to

Answer 4

substantially reduce PVR in chronically hypoxic lungs (Reviewed by Rowan et al. 2016)