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Blood Bank II Summer > The Red Cell Component (lect 2) > Flashcards

The Red Cell Component (lect 2) Flashcards

1
Q

LRBC

A

leukoreduced rbcs

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2
Q

Transfusion therapy
risk and benefits

A

risks: rejection, exposure to pathogens, cllinical repercussions

Benefits: blood oxy content, iron, hemostasis, cardiac output

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3
Q

Blood Component preparation
things made from whole blood

A

rbcs
granulocytes
plts
plasma
cryo
clot factor derives
rhogam
igs
antisera
alb

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4
Q

Whole blood statistics
vol
storage
shelf life
HCT
fibrinogen

A

vol - 450-500ml
Storage 2-6 c
Shelf life 21 days CPD
HCT - 38%
Fibrino - 1000mg

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5
Q

Whole blood is used for…

risks? (autologous units?)
MUST?

A

volume expansion and oxygen capacity
“autologous units”

Risk of circulatory overload

MUST match forwards and reverse

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6
Q

In order to collect and process blood, a facility must submit to ?

A

FDA inspection

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7
Q

PLT (deciding to use whole blood for plts)

A

Cool to RT
20-24 c within 24hr

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8
Q

Plasma (deciding to use from whole blood)

A

cool to 1-10c within 8hr

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9
Q

Whole blood from apheresis
what distinguishes it from regular procedure?

A

intermitten and continous flow distinguish from regular procedure

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10
Q

Deferral requirements for donors

A

40% HCT 16 wk deferral

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11
Q

Risks of apheresis whole blood donation

A

citrate toxicity
vascular access
vasovageal rxns

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12
Q

Clinical treatment of whole blood
Plasmapheresis
Photophoresis
Erythrophoresis

A

Plasma - warm auto
Photo - leukemia
Erythro - sickle cells

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13
Q

ISBT label

A

Donor, expiration, description..etc

E-CODE- what type of product this is and what has happened to it

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14
Q

Leukocyte reduced/packed rbcs
LRBC/PRBC
stats

Vol
Hct
shelf life
temp

A

Reduced: <5 x 103 wbc count

Vol: 250-300ml (apheresis vol exact is listed)

Hct: 60-85% (<80 desirable)

Shelf life 21-42 days

TEMP 2-6 degrees

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15
Q

LRBC/PRBC used for

Expected outcome

Risks

A

most common rbc component
(reduced HLA exposure/fever)

Expected: incr hgb 1g/dL or HCT 3% 24hr after completion

risk: graft vs host: patho exposure

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16
Q

T/F there is plasma in LRBC/PRBC

A

NO plasma in product

17
Q

Previously frozen deglycerolized rbcs (DRBC)

stats
vol 1
temp -6
shelf 1
hct 7

A

180ml
-65 c
10yr shelf life (once washed its 24hr expiration)

Hct 70-80% (75% viability)

18
Q

DRBC used for

good for?

risks?

A

incr hgb 1g/dL or HCT 3%

good for RARE AG or pts with ALLERGIC RXNS

Risk: degradation of cells, left over glycerol, bag damage

19
Q

Irradiated packed rbcs (IRBC)
stats
vol 3
temp 2
shelf 2
hct 6

irradiated with?

A

300ml
2-6 c
28 days post irradiation/expiration
Hct 60-85% (<80%)

irradiated with 25-gy cesium 137 or cobalt 60

20
Q

Risks of IRBCS

what changes?

used in?

A

rbc have higher degradation after irradiation, HLA immunization

color changes on tag after irradiation

used in immunocompromised pts

21
Q

Storage and visual inspection:

maintain temp

A

2-6 c storage
1-10 c transferring from sites
“30 min rule” blood being out of lab

22
Q

Visual inspection

A

daily, on reciept, crossmatch, issue, return

23
Q

during visual inspection, look for…

A

hemolysis
Limpemia- more obvious in plasma components/strawberry milk
Bacterial contam
Particulate matter - clots
Discoloration

24
Q

Components that leave for transfusion, returned unspiked at 1-10c

A

to keep

25
Q

washed deglycerolized rbcs <24hr from wash

A

keep

26
Q

rbc aliquot seal failure <24hr

A

keep

27
Q

Components in validated coolers outside of the lab at 2-6 c

A

keep

28
Q

autologous units after pt discharge

A

discard

29
Q

unit retype doesnt match label

A

discard

30
Q

RBC substitues: Hemoglobiin based oxy carriers (HBOC)

pros
cons

A

Cell free hgb
used for trauma/sickle cells

Pros: delivers oxy quickly to change affinity

Cons: vasoconstriction, renal failure, short half life

31
Q

Universal RBC engineering

A

gut bacteria remove A or B or H sugars
creation of univeral donor from any blood

32
Q

What factors are highest in cryoprecipitate

A

Factor 5 and 8

Blood Bank II Summer (9 decks)

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