HDFN (After exam 1) Flashcards
Maternal perspective
what to detect?
DAT to detect if ab has attached to rbs
+ DAT on baby blood
HDFN
+ DAT on anyone
elution/AB id
Predictions
what testing?
ABO types?
Predict?
type and screen
ABO : O Neg mom more likely to have HDN than AB pos
predict what Ab mom could make
HDFN
what is destroyed by….
specific for ?
what sensitizes mother?
fetal rbcs destroyed by maternal Allo ab specifc for inherited paternal rbc ag
Fetal rbcs sensitize mother: trauma, delivery, abortion, medical intervention
O patients commonly make?
IgG A,B
Characteristics of HDFN Ab
can?
not absorbed?
causes? (efficient)
positive?
can cross placenta IgG
not absorbed by normal tissues
causes hemolysis: igG1/IgG3 efficient
+ on fetal cells
Ab in HDFN
common ab: A/B, D, Rh, Kell
Rare: duffy, Ss, Kidd, MN
Post partum testing: Mother
blood type and screen, Ab ID, betke…etc
Post partum testing: infant
blood type, DAT, elution
Followup test to maternal ID
Ab titer,
must to successive titers
Diagnosis/ management of HDFN
initial visit
hxt
Transfusion/pregnancy Hxt
type+screen
Rh status
Ab Id/ titration
Subsequent visits for management of HDFN
Ab titrations
ab panels
26-38 wk visits for management of HDFN
confirm ag neg of fetus.
rhogam admin if necessary
Rhogam
ONLY directed at ANTI-D, only for prevention not great for treatment
