HDFN (After exam 1) Flashcards

1
Q

Maternal perspective
what to detect?

A

DAT to detect if ab has attached to rbs

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2
Q

+ DAT on baby blood

A

HDFN

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3
Q

+ DAT on anyone

A

elution/AB id

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4
Q

Predictions

what testing?

ABO types?

Predict?

A

type and screen

ABO : O Neg mom more likely to have HDN than AB pos

predict what Ab mom could make

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5
Q

HDFN
what is destroyed by….

specific for ?

what sensitizes mother?

A

fetal rbcs destroyed by maternal Allo ab specifc for inherited paternal rbc ag

Fetal rbcs sensitize mother: trauma, delivery, abortion, medical intervention

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6
Q

O patients commonly make?

A

IgG A,B

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7
Q

Characteristics of HDFN Ab
can?
not absorbed?
causes? (efficient)
positive?

A

can cross placenta IgG
not absorbed by normal tissues

causes hemolysis: igG1/IgG3 efficient

+ on fetal cells

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8
Q

Ab in HDFN

A

common ab: A/B, D, Rh, Kell

Rare: duffy, Ss, Kidd, MN

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9
Q

Post partum testing: Mother

A

blood type and screen, Ab ID, betke…etc

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10
Q

Post partum testing: infant

A

blood type, DAT, elution

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11
Q

Followup test to maternal ID

A

Ab titer,
must to successive titers

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12
Q

Diagnosis/ management of HDFN

initial visit

hxt

A

Transfusion/pregnancy Hxt

type+screen

Rh status
Ab Id/ titration

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13
Q

Subsequent visits for management of HDFN

A

Ab titrations
ab panels

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14
Q

26-38 wk visits for management of HDFN

A

confirm ag neg of fetus.
rhogam admin if necessary

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15
Q

Rhogam

A

ONLY directed at ANTI-D, only for prevention not great for treatment

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16
Q

Lab monitoring/titration
Critical titer for Anti D

A

16-32 AHG phase

17
Q

Critical for anti K

A

8

18
Q

if a titer is <8, when may the next be preformed?

significant change?

A

next may be preformed every 4-6wk

sign change defined by diff of 2 dilutions

19
Q

Significance of D

critical value?

A

extremely immunogenic

1mL can sensitize mother

Critical Value >16 TITER

20
Q

Weak D test

serologically?
poly?
verify?

for?

A

serologically IS/AHG

polyclonal D
verify w saline

for donors or discrepency

21
Q

Molecular
what panel?

females of….

Rh pos but?

A

SNP panel

females of child bearing age with Weak D

Rh pos but Anti D demonstrated

22
Q

Rhogam continued

class
high
bleed?

criteria?

A

Rh immunoglobulin

high titer IgG anti-D

30 mL Bleed

Criteria: Rh neg

NO HXT OF ANTI D

23
Q

Fetal maternal bleed screen

what formation
baby and mother rh status?

tests for?

negative results

positive results

A

rosettes, mother Rh =

baby Rh +

qualitiative test for the fetal maternal hemorrage

Negative results: <15mL bleed give standard dose

Positive: >15ml bleed, quantitate test for dose

24
Q

Kleinhaur betke

what kind of test? (non) testing for?

equation?

A

quantitative test, fetal hgb non invasive

fetal cells/#maternal cells = % bleed

% bleed x maternal vol (5000/30) = dose + 1

25
Q

FNA-TP
most common?
therapy?
causes?

A

HPA-AI

IVIG therapy
TP

26
Q

ITP

A

prednisone
alloimmune