the posioned patient Flashcards
opioid toxidrome classic triad
miosis
lethargy
respiratory depression
mainly action at mu receptor
opioid withdrawal treatment
methadone or buprenorphine
Anticholinergic toxidrome treatment
benzodiazapene
Physostigmine
Supportive care
minimize stimuli
Anticholinergic toxidrome
Mad as a hatter Blind as a bat (mydriasis) Red as a beet Hot as a desert Dry as a bone
Cholinergic toxidrome
caused by anticholinesterases
nictonic effects from cholinergic receptor
muscarinic effects (DUMBBELS)
DUMBBELS
(leakyness) from muscarinic cholinergic toxidrome
diarrhea urination miosis bronchorrea bradycardia emesis lacrimation salivation
Cholinergic toxidrome treatment
atropine for carbamate
pralidoxime a cholinesterase reactivator for OPs (irreversible inhibition of AchEase
strychnine
when inhaled causes poisoning resulting in muscular convulsions and eventually death by asphyxia. can be confused with tetanus
antidotes mechanism of action
physically bind and disable toxicant (pralidoxome) pharmacolic antagonism (atropine) increase detoxification systems (n-acetylcysteins)
acetoaminophen OD
NAPQI metabolite causes oxidant tissue damage
acutley poisoned patient treatment
supportive care is #1
prevent absorption
enhance elimination
antidotal therapy
n-acetycystein OD can cause what failure?
hepatic failure
