metals

Question 1

inorganic mercury mechanism

Answer 1

binds to sulfhydryl containg enzymes

disrupts cell function

Question 2

inorganic mercury treatment

Answer 2

chelation (BAL, DMSA, D-penicillamine)

Question 3

organic mercury treatment

Answer 3

chelation (DMSA,DMPS)

Question 4

Thallium mechanism

Answer 4

enters cell through K+ channels and binds to sulfhydryl groups and inhibits many things

Question 5

Thalium poisoning

Answer 5

alopecia (hair loss)
mees lines
skin changes (red)
severe peripheral neuropathy
constipation

Question 6

elemental mercury mechanism

Answer 6

direct pulmonary toxicity when inhaled
highly lipid soluble
ionized to Hg1 or HG2
binds to sulfhdryl enzyme systems
disrupts cells

Question 7

arsenic mechanism

Answer 7

binds thiol groups
uncoupes oxidative phosphorylatioin
inhibits krebs cycle enzyme

Question 8

arsenic treatment

Answer 8

gastrointestinal decontamination
activated charcoal
chelation

Question 9

arsenic chelators

Answer 9

DMSA (succimer)

Question 10

treatment mercury poisoning

Answer 10

inorganic - chelation (BAL. DMSA, D-Penicillamine)
Organic - chelation (DMSA, DMPS)
elemental - depends

Question 11

antidote for thalium

Answer 11

prussian blue

Question 12

antidote for iron

Answer 12

deferoximine. finds iron and folds around iron and forms ferrioximine which comes out through urine. rust color is a lot of iron excreted and more clear urine is less iron coming out

Question 13

lead lines only show in?

Answer 13

children whos joints have not closed. by 13 14 joints have closed

Question 14

colloidal means

Answer 14

anything in zero oxidative state that is super divided into small molecules that they stay suspended in the solution

Question 15

silver poisoning (argyria)

Answer 15

silver sits on skin and makes blue

Question 16

over the counter GI product

Answer 16

bismuth toxicity

Question 17

mptp

Answer 17

damages brain
parkinsons disease
basal ganglia (controls movement and balance) gets destroyed

Question 18

gadolinium

Answer 18

thickening discoloration of skin
chronic renal failure
tense muscles

Question 19

two gadolinium used in health care

Answer 19

linear agents. = do not fully surround Gd ions

macrocyclic agents = fully enclose GD ions with nitrogen

Question 20

cesium 137 radiation poisoing

Answer 20

skin burn
used to prevent or treat cancer
mimicks potassium in the heart