The oral and intestinal mucosal immune system Flashcards
What is the three major components of the mucosal immune system for both the oral and digestive tract?
epithelial layer
lamina propria
mucosal associated lymphoid tissue (MALT)
what occurs in the lamina propria?
rich with vasculature, lymph vessels and immune cells, KEY for immune responses to occur
what is MALT?
organized lymphoid follicles
peyers patches in intestines, tonsils and adenoids in oral
what is found within the epithelial layer?
microfold cells (transfer antigens to APC)
tuff cells (chemosensors)
paneth cells (secrete antimicrobials)
what does ILC1 become activated?
bacterial, viral and protozoal infection
what are the major subsets of immune cells in the oral cavity?
ILC1 and ILC3
What does ILC3 do?
produce IL 17 and 22 when bacterial and fungal infection
what are peyers patches?
group of well organized lymph follicles in lamina propria
what is the T cell responses n the lamina propria?
project dentdites into the epthelium to uptake antigens and migrate them peyers patch where they prime naive cells
what helper t subsets are in peyer patches?
TH1, TH2, TH17, TH22, follicular helper T, regulatory T cells
what produces the cytokine that is key in fighting the two major oral disease types?
Th17 and Tgd produce IK17
what is in the parafollicular zone of peyer patches?
Tab
what makes up a significant portion of innate like immunity cells in the oral and intestinal mucosa?
Tgd and NKT cells
IgM can differentiate into what in the peyers patch follicles?
IgA secreting plasma cells
what is IgA role in the complement system?
activates it through alternative and lectin path NOT classical
where is IgA in the oral cavity?
salivary gland and saliva (resident IgA memory B lymph are abundant in germinal centers)
what is important in tolerance of normal flora?
T reg and THF B
(THF B stim production of IgA antibodies which promotes the integrity of mucosal immunity)
What is the primary function of T helper 17 (TH17) cells in mucosal immunity?
A) Mediating production of IgA antibodies
B) Secreting IL-17 to defend against fungal infections
C) acting as a down-regulator to ensure tolerance to commensal microbiota
D) Inducing differentiation of B lymphocytes into plasma cells
E) Acting as antigen-presenting cells
B) Secreting IL-17 to defend against fungal infections
Which of the following statements about IgA in oral mucosal immunity is
CORRECT?
A) IgA activates the classical complement pathway.
B) IgA is secreted by Paneth cells in the mucosal epithelium.
C) IgA is primarily found in salivary glands and saliva in the oral cavity.
D) IgA+ memory B cells are absent in Peyer patches
E) IgA is involved in tolerating pathogenic microbes
C) IgA is primarily found in salivary glands and saliva in the oral cavity.
