The Nervous System Flashcards
Describe the main features of the nervous system
- Maintains internal coordination with electrical/chemical signals
- Contains CNS (brain+spinal cord) and PNS (sensory and motor divisions)
Describe the CNS
- Central nervous system
- Brain and spinal cord
- Process, store and retrieve information
Describe the PNS
- Peripheral nervous system
- Delivers signals to/out of CNS
-
Sensory
- Sends signals to CNS
- Brings sensation
-
Motor
- Sends signals from CNS to glands/muscles
- Brings response
-
Somatic
- Connect to skin, muscle, or bone joint
- Voluntary muscles
-
Visceral
- Connect to internal organs
- Involuntary muscles
Describe neurons and its properties
- Functional unit of the nervous system
- Excitability: Responsive to stimuli
- Conductivity: Transduce signals
- Secretion: Secrete neurotransmitter to stimulate another neuron
What are the functional classes of neurons, based on function?
-
Sensory (afferent)
- Transduce signals from receptors to CNS
-
Interneurons
- Integrative function
- 90% of neurons in human body
-
Motor (efferent)
- Send signals to muscles/glands
Describe the structure of a neuron
-
Cell body
- Soma
- Organelles e.g. nucleus, mitochondria
- Neurofibrils: network to maintain shape
-
Dendrites
- Receive signals from other cells
-
Axons
- Conduction of signals to other cells
- Myelin sheath
What are the functional classes of neurons, based on the appearance?
-
Multipolar
- One axon + 2> dendrites
-
Bipolar
- Two neurites (dendrite or axon) from soma
- One axon + One dendrite
-
Unipolar
- One neurite from soma
- Psuedounipolar
What are the types and functions of neuroglia?
- Protects neurons, aids their function
- “Stick” neurons together via a framework
- CNS
- Oligodendrocyte: Wrap axons to form myelin sheath
- Ependymal cells: Lines the central cavity, produces cerebral spinal fluid
- Microglia: Immune cells
- Astrocytes: Forms supportive framework and blood-brain barrier
- PNS
- Schwaan cells: Wraps to ONE myelin sheath, nerve regeneration
- Satellite cells: Surrounds neurons at ganglion (soma)
What is the myelin sheath?
- Insulating layer around nerve fibre
- Speed up nerve signal transduction
- Formed by oligodendrocyte (CNS) and Schwaan cells (PNS)
- Composed of protein and lipids
What are the functions and forms of synapses?
- Meeting point between neuron and other cells
- Decision-making device
- Forms
- Axodendritic: between axon and dendrite
- Axosomatic: between axon and soma
- Axoaxonic: between axon and axon
What are the types of synapses?
-
Chemical
- Separated by synaptic cleft
- Cell adhesion molecules (CAM) connect pre and post-synaptic neurons
- Release neurotransmitters
-
Electrical
- Gap junctions
- Allows ions to diffuse
Acetylcholine: stimulates muscles
Norepinephrine: stimulates organs
Describe the functions of the spinal cord
- “Information highway” that connects brain with lower body
- Conduction
- Neural integration
- Locomotion: controls repetitive muscle contractions
- Reflexes: involuntary responses
Describe the surface anatomy of the spinal cord
- Cervical, thoracic, lumbar, sacral regions
- Enlargement areas
- Nerve tissues to innervate limbs
- Cervical: nerves for upper limbs
- Lumbosacral: nerves to pelvic and lower limbs
- Cauda equina
- Innervates pelvic and lower limbs
What are the meninges in the spinal cord?
- Protective membranes
-
Dura mater
- Outer layer
- Tough collagenous
-
Arachnoid mater
- Looser
- Space filled by CSF (shock absorbance)
-
Pia mater
- Inner layer
- Delicate, transparent
- Anchoring
Describe the cross-sectional anatomy of the spinal cord
Gray and white matter
-
Gray matter
- Contains posterior and anterior horns
- Lateral horns at thoracic and lumbar regions
- Gray commissure joins right and left sides
- Central canal in middle
-
White matter
- Surrounds gray matter
- Consists of bundles of axons
- Posterior, lateral, and anterior columns
What are the spinal tracts?
- White matters in spinal cord
-
Ascending
- Carry sensory info up the cord to the brain
- First-order neuron: detects stimulus
- Second-order neuron: to thalamus
- Third-order neuron: to sensory cortex
- Spinothalamic: signals for pain, temp, pressure
-
Descending
- Carry motor impulses down to muscles
- Upper motor neuron: from cortex down spinal cord
- Lower motor neuron: to muscles/organs
- Decussation (cross-over) may be found
What is a nerve?
- Collection of numerous nerve fibres (axon) bound together
- Fascicle: collection of axons
- Nerve: collection of fascicles
- Mixed nerve: sensory and motor neurons
Name the branches of spinal nerves
-
Anterior Ramus
- Innervate skin and muscles on anterior/lateral side
-
Posterior Root
- Innervate skin and muscles on back of body
-
Meningeal Branch
- Innervates meninges, vertebrae, spinal ligaments
What are the nerve plexuses?
- Cervical: C1 to C5, innervate diaphragm, neck, and back muscles
- Brachial: C5 to T1, innervate upper limb, neck, and shoulder muscles
- Lumbar: L1 to L4, innervate hip, thigh, scrotum
- Sacral and Coccygeal: L4 to S4
Clinical application
What are the three major parts of the brain?
-
Cerebrum
- Left and right hemispheres
- Separated by longitudinal fissure
- Connected by Corpus callosum
- Gyrus: thick folds
- Sulcus: deep grooves
-
Cerebellum
- Separated by cerebrum by transverse cerebral tissue
-
Brainstem
- Essential for vital functions
- Continues as spinal cord inferiorly
Describe the cross-sectional anatomy of the brain
Gray and white matter
-
Gray matter
- Outer surface of cerebrum
- Nuclei: neuronal soma
-
White matter
- Bundle of axons
- Connects brain to spinal cord
What are the meninges in the brain?
- Protective membranes
-
Dura mater
- Dense fibrous connective tissue
- Periosteal: attached to cranial bones
- Meningeal: inner layer
- Falx: inner foldgins
-
Dural sinuses
- Space between dural tissue
- Collects blood and empties into veins
-
Arachnoid mater
- Looser
- Space filled by CSF (shock absorbance)
-
Pia mater
- Inner layer covering cerebrum
- Delicate, transparent
Describe the ventricular system of the brain
-
Lateral
- 2 in each cerebral hemisphere
-
Third
- Connected to lateral
- Via ventricular foramen
-
Fourth
- Connected to third
- Via cerebral aquedect
- Continues as central canal in spinal cord
-
Choroid Plexus
- Produces CSF
What are the functions of cerebrospinal fluid?
- Provide buoyancy: prevent brain from collapse
- Protection: prevent from striking cranium
- Chemical stability: remove metabolic wastes
What is the brain barrier system?
- Blood-brain barrier: Astrocytes contact blood capillaries, stimulate tight junctions between endothelial cells
- Blood CSF barrier: formed at choroid plexus
Describe the functions of medulla oblongata (the most inferior part of the brainstem)
- Contains all nerve fibres between brain and spinal cord
- Four pairs of cranial nerves
- Cardiac center: regulate heartbeat rate and force
- Vasomotor center: regulate BP and vasoconstriction
- Respiratory center: regulate breathing rate and depth
Describe the appearance of the medulla oblongata (the most inferior part of the brainstem)
- Surface
- Pyramids: clublike ridges
- Separated by anterior median fissure
- Internal
- Ascending and descending tracts
- Nucleus
- Fourth ventricle
Describe the features of the pons
- Rostral to the medulla
- Cerebellar peduncles: connected to cerebellum
- Four pairs of cranial nerves begin/end
- Internal structures
- Ascending and descending tracts
- Part of fourth ventricle
Describe the features of the midbrain
- Superior to the pons
- Cerebral aqueduct passes through
-
Colliculus (bumps)
- Superior: visual reflex (blinking) and visual attention (tracking movement)
- Inferior: auditory reflexes (startle reflex)
- Internal structures
- Ascending and descending tracts
- Central gray: pain awareness
- Substantia nigra: motor center, suppress unwanted motor action
Describe the appearance of the cerebellum
- Two hemispheres connected by vermis (narrow wormlike bridge)
- Folia: gyrus
- Connect to
- Medulla via inferior peduncles
- Pons via middle peduncles
- Midbrain via superior peduncles
- Internal structures
- Arbor vitae: white matter
- Neurons: Granule cells and Purkinje cells
Describe the functions of the cerebellum
- Motor coordination center
- Learning motor skills
- Maintain muscle tone and posture
- Coordinate eye and body movement
- Coordinate complex action
- Receives info from cerebrum and joints