The Central Dogma Flashcards
DNA
Genetic information arranged on chromosomes organized into genes
Constituitive Genes
+Transcriptionally controlled
+ Always expressed
+ Housekeeping genes provide basic cellular function
+ Occur in most cell types
Regulated or Inducible Genes
\+ Transcriptionally controlled \+ Expression turned on/off \+ Cell-specific functions \+ Development signals \+ Environmental stimuli
Epigenetic Regulation
+ DNA modifications that affect gene expression
+ Histone modifications
+ Passed on to next generation in some cases
Replication
+ Duplication of genome in preparation for cell division
+ Enzymatic polymerization of deoxyribonucleotides into DNA bases on DNA sequence
Transcription
+ Enzymatic polymerization of ribonucleotides into RNA based on DNA sequence of gene
Translation
+ Enzymatic polymerization of amino acids into a protein based on RNA sequence
Purines (Pu, P)
+ Adenine and Guanine
+ 9 member dicyclic ring
+ Nitrogenous base
Pyrimidines (Py, Y)
\+ Cytosine, Thymine, and Uracil \+ 6 member ring \+ Nitrogenous base \+ Uracil only with ribose \+ Thymine only with deoxyribose
Nucleotides
Base + Sugar + Phosphate
Nucleosides
Base + Sugar
N (nucleoside)
Base + Ribose
dN (nucleoside)
Base + 2-Deoxyribose
NMP (nucleotide)
Base + Ribose + Pi
dNMP (nucleotide)
Base + 2-Deoxyribose + Pi