The Cell Surface Flashcards
4 major phospholipids
- Phosphatidylethanolamine
- Phosphatidylserine
- Phosphatidylcholine
- Sphingomyelin
What does cholesterol do?
- Increases rigidity
- Decreases permeability to small molecules
What do intracellular signal transduction lipids do?
- Bind specifically to certain regions of proteins
- Cause conformational, localization and/or activity change(s)
What does fluidity of membranes allow?
- Signalling lipids and membrane proteins to rapidly diffuse laterally
- Membrane to be shared equally by daughter cells
- Membranes to fuse with other membranes
Integral and peripheral membrane proteins
- Single-pass
- Multi-pass
- Beta-barrel
- Lipid-linked
- Peripheral membrane
Functions of membrane proteins
- Transport
- Enzymatic activity
- Signal transduction
- Cell-cell recognition
- Intercellular joining
- Attachment to cytoskeleton and extracellular matrix
Factors affecting ability of solute to simply diffuse across a membrane
- Concentration gradient
- Hydrophobicity/charge
- Size
2 classes of membrane proteins involved in facilitated diffusion
- Channels
- Uniporter carrier proteins
What do channel proteins form in the membrane?
Hydrophilic pores
Speed of channel proteins
10^7 ions per second
How do uniporter carrier proteins work?
Solute binds to the binding site
Speed of uniporter carrier proteins
<1000 molecules per second
Why do cells maintain electrochemical gradients?
- Drive transport
- Maintain osmotic balance
- Electrical forces inside and out must be balanced
What protein is used to maintain Na+ electrochemical gradient?
Na+/K+ ATPase
Why is Na+/K+ ATPase both a carrier and enzyme?
Also hydrolyses ATP to ADP