The B cell - L8B Flashcards
what is a B cell
type of WBC that makes antibodies
name two functions of B cells
antigen presentation to T cells
Activate T helper cells
name the 3 types of antigens
Sensed by b cells
- non-protein antigens
- extracellular antigens
- intracellular antigens
what do non-protein antigens do
activate B cells directly via triggering B cell receptor
what do extracellularantigens
B cells undergo affinity maturation and class switch
how do B cells develop
- foetal liver
- bone marrow
- periphery
how do B cells differentiate and mature
- multiple checkpoints
- Pre B cell which then achieves a stimulus through B cell receptor
is there an antigen in the bone marrow
no
When are b lymphocytes generated
largely in the absence of antigens
what 2 things are the B cell receptor composed of
membrane bound immunoglobulin
signal transduction element
what is the cognitive phase of B cell activation
Naïve B cell stimulated with antigen
Clonal stimulation
what is the activation phase of B cell activation
- Proliferation of selected cell
- Differentiation into plasma cell
what do thymus dependant B cells need
help from T cells to produce antibodies
what do plasma cells do in Naive B cells
secrete antibodies and are short lived
what do long lived B cells do
secrete antibodies continuously without antigen
