clinical virology - L6B

Question 1

give 3 reasons why viruses are a big medical problem

Answer 1

can remain infectious

have pandemic potential

require killing the cell to kill the virus

Question 2

what is chicken pox caused by

Answer 2

double stranded DNA virus of Herpes family

Question 3

how is chicken pox spread?

Answer 3

enter respiratory tract

infectious droplets

via blood stream

Question 4

what is the symptoms of chickenpox

Answer 4

papular rash

Question 5

give facts about influenza

Answer 5

highly airborne virus

single stranded RNA virus

negative sense

enveloped virus with glycoproteins

Question 6

what are Haemagglutinin and neuraminidase

Answer 6

glycoprotein spikes

Question 7

what is Haemagglutinin involved in

Answer 7

attachment

Question 8

what is neuraminidase involved in

Answer 8

release

Question 9

what is the antigenic DRIFTS

Answer 9

amino acid changes

Question 10

what is antigenic SHIFT

Answer 10

Two or more strains combining to make a new subtype

Question 11

what is reassortment

Answer 11

if two influenza viruses infect same cell, then segments from both genomes can mix to generate a new virus

Question 12

describe ebolas biology

Answer 12

single stranded

linear

negative sense

RNA genome

helical capsid

Lipid envelope

Question 13

how is ebola spread?

Answer 13

bodily fluids

direct contact

Question 14

what are symptoms of ebola

Answer 14

haemorrhage

shock

vascular permeability

Question 15

treatment for ebola

Answer 15

blood transfusions

oxygen supplement

Question 16

what is the new treatment idea ofr ebola?

Answer 16

using whole blood or plasma from survivors

Question 17

Name 3 viruses associated with cancer

Answer 17

• Hepatitis B
• Hepatitis C
• Epstein Barr

Question 18

which other disease is there a correlation with Human Papilloma virus?

Answer 18

Cervical cancer

Question 19

name facts about Epstein Barr virus

Answer 19

• acute illness
• infects B cells
• drives a latent infection

Question 20

what is Burkitt lymphoma associated with?

Answer 20

malaria prevalence

Question 21

what is Hepatitis?

Answer 21

liver inflammation

Question 22

how is hepatisis B transmitted?

Answer 22

via blood

Question 23

is hepatitis RNA or DNA

Answer 23

double stranded DNA

Question 24

what is a mature virus called?

Answer 24

Dane particle

Question 25

is hepatitis B preventable?

Answer 25

yes

Question 26

name 3 reasons why its difficult to make a viral vaccine

Answer 26

high MUTATION rates which makes them ineffective

few viral proteins

numerous ANTIGENIC types

Question 27

is small pox DNA or RNA

Answer 27

complex DNA double stranded virus

Question 28

is small pox + or - envelope

Answer 28

both

Question 29

how is smallpox spread

Answer 29

person to person via aerosol

Question 30

what family does small pox belong to

Answer 30

variola family

Question 31

what are 3 symptoms of small pox

Answer 31

spotty rash

blindness

arthritis

Question 32

can small pox be fatal

Answer 32

yes - when there is a haemorrhage

30 % mortality

Question 33

which is the only virus successful story

Answer 33

smallpox