Tetracyclines

Question 1

Tetracyclines (4 drugs)

Answer 1

Doxycycline
Minocycline
Tetracycline
Tigecycline

Question 2

Tetracyclines MOA

Answer 2

Competitive inhibition of tRNA binding to 30S subunits. Prevents addition of new amino acids to the peptide chain. Bacteriostatic

Question 3

Tetracycines indications

Answer 3

Lyme disease, Rocky mountain spotted fever, ehrlichiosis, granuloma inguinale, brucellosis, cholera, relapsing fever, PUD (H. pylori), chlamydia urethritis, acne, MRSA

Question 4

Tigecycline - indications

Answer 4

MRSA (skin & soft tissue inf), intraabdominal infections, community acquired pneumonia

Question 5

Tetracycline that can only be adm intravenously

Answer 5

Tigecycline

Question 6

Tetracyclines should not be taken with:

Answer 6

Calcium, aluminum, iron, dairy products, antacids (reduces bioavailability of tetracycline)

Question 7

Spectrum of tetracyclines, bacteriocidal or -static

Answer 7

Broad-spectrum, bacteriostatic

Question 8

Most effective group of drugs for acne vulgaris

Answer 8

Tetracyclines

Question 9

Tetracycline used often for acne

Answer 9

Minocycline

Question 10

Tetracyclines - contraindications

Answer 10

Pt growing teeth and bone, pregnancy, use of nephrotoxic drugs (aminoglycosides), expired drug preparations (more nephrotoxic)

Question 11

Tetracyclines - adverse effects

Answer 11

Discoloration of teeth, hypoplasia of enamel. Nephrotoxicity, hepatotoxicity, photosensitivity (erythema)

Question 12

Tetracycline most associated to photosensitivity

Answer 12

Doxycycline