Chloramphenicol, Clindamycin, Quinupristin-dalfopristin

Question 1

Chloramphenicol, clindamycin, quinpristin-dalfopristin - classification

Answer 1

50S inhibitors

Question 2

Clindamycin - indications

Answer 2

Inf by methcillin-resistant staph, and penicillin-resistant strepts (necrotizing fasciitis).
Gas gangrene
Acne vulgaris

Question 3

Clindamycin - side effects

Answer 3

Superinfections (severe diarrhea, psuedomembranous colitis)

Question 4

Clindamycin - contraindications

Answer 4

Diarrhea - discontinue treatment

Question 5

Chloramphenicol - indications

Answer 5

Meningitis

Question 6

Chloramphenicol - adverse effects

Answer 6

Gray baby syndrome
Reversible, dose-dependant anemia
Aplastic anemia

Question 7

Chloramphenicol - spectrum & bacteriocidal/ - static

Answer 7

Broad spectrum, both bacteriostatic and bacteriocidal.

Question 8

Streptogramins (2 drugs)

Answer 8

Quinupristin

Dalfopristin

Question 9

Why is quinupristin and dalfopristin used together?

Answer 9

Act synergistically to inhibit different sites of the 50S subunit

Question 10

Quinupristin - MOA

Answer 10

Prevents addition of new amino acids by inh aminoacyl tRNA synthesis

Question 11

Dalfopristin - MOA

Answer 11

Blocks peptide bond formation by inh peptidyl transferase

Question 12

Quinupristin-Dalfoprisitn - indications

Answer 12

Bacteremia, peritonitis, endocarditis, aortic graft inf by vancomycin-resistant bact.
Pneumonia, soft-tissue & skin inf

Question 13

Quinupristin-dalfopristin - adverse effects

Answer 13

Infl of veins, arthralgia, myalgia, diarrhea, nausea