Tetracycline

Question 1

Examples:

Answer 1

Tetracycline,Doxycucline, Minocycline,

Question 2

MOA:

Answer 2

Bbinds to the 30S ribosomal subunit with consequent misreading of information for protein synthesis 🡺 Inhibition of bacterial protein synthesis= (Bacteriostatic)

Question 3

Adverse reactions

Answer 3

Photosensitivity

GI disturbances

Hypersensitivity reactions

Discoloration of teeth (If given in midpregnancy-5months deciduous teeth are affected)

Late pregnancy or childhood, can cause temporary suppression of bone growth

Question 4

Drug interactions:

Answer 4

Divalent metal ions: Interfere with absorption and activity.

Enzyme inducers (barbiturates, phenytoin etc) reduce serum level of tetracycline

Inhibit Vit K producing intestinal flora, thus can potentiate the anticoagulant effect of warfarin