Macrolides

Question 1

Examples

Answer 1

Examples: Erythromycin, Azithromycin, Clarithromycin

Question 2

MOA:

Answer 2

Inhibit protein synthesis by blocking polypeptide exit tunnel on 50S subunit (Bacteriostatic)

Question 3

Adverse reactions:

Answer 3

GIT problems
Mild allergic reaction
Reversible hearing loss
Liver toxicity
Jaundice

Question 4

Drug interactions:

Answer 4

Digoxin-increased level of dioxin can occur

Increased effects of anticoagulant, theophylline and corticosteroids