Sulfonamides

Question 1

Sulfonamides

Answer 1

Usually supplied as a combination products having two main components, a sulfonamide and trimethoprim

Examples: Sulfamethoxazole, Sulfasalazine, Sulfisoxazole

Question 2

MOA:

Answer 2

Inhibition of folic acid synthesis (bacteriostatic)

Question 3

Adverse reactions:

Answer 3

Hypersensitivity reactions such as
* Rashes,
* Erythema multiforme of Stevens-Johnson type
* Exfoliative dermatitis
* Photosensitivity
* Nausea
* Vomiting and
* Headache

Question 4

Drug interactions:

Answer 4

Phenytoin (phenytoin toxicity)
Tolbutamide (hypoglycaemia) and
Warfarin (enhanced anticoagulation)