Nitroimidazole Flashcards
1
Q
Examples
A
Metronizadole
2
Q
MOA:
A
Interacts with DNA by releasing free radicals
🡺cause strand breakage
🡺inhibition of protein synthesis (Bactericidal)
3
Q
Adverse reactions:
A
Peripheral neuropathy
Nausea, vomiting, diarrhea
Metallic taste
Seizures (on prolonged and high doses
4
Q
Drug interactions:
A
Mild disulfiram like reactions(nausea, headache
Potentiates anticoagulant
Phenytoin increases metabolism of metronidazole
