Aminoglycosides

Question 1

Examples

Answer 1

Gentamicin
Amikacin
Streptomycin

Question 2

MOA

Answer 2

MOA: Bind to a particular protein in the 30S and 50S subunit of the bacterial ribosomes

🡺Misreading of m-RNA codons
🡺 Inhibition of bacterial protein synthesis (Bacteriostatic)

Question 3

Adverse reactions:

Answer 3

Ototoxicity
(CN VIII) (mainly relating to dose) patient may have symptoms of fullness in the ears, tinnitus, or vertigo.

Nephrotoxicity
(Increased by pre-existing renal damage & by co-administration with certain cephalosporins and loop diuretics

Question 4

Drug interactions

Answer 4

Cefalothin, cefaloridine, polymyxins, loop diuretics
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