Testosterone deficiency Flashcards
Definition of testosterone deficiency?
clinical AND biochemical syndrome of low testosterone
What is primary vs secondary testosterone deficiency?
Primary- testicular issues
secondary- hypothalamic, pituitary and idopathic reasons
WHen is the drop off of testosterone?
35
What happens as we age for their to be low testosterone?
low production and SHBG binds more testosterone
How much test is free?
2 BUT 38% weakly bound to albumin
Sx of low test?
tired, low libido, mood issues, less muscle, osteoporosis, more fat, anemia
Are screening tools useful for low test?
NO
What test must you do before giving test?
check prostate because can make prostate cancer worse
What can cause low test?
opioids, DM, renal issues, HIV, obese, concussion
What test for testosterone should you use?
BIOAVAILABLE/free
CI of testosterone?
breast cancer/prostate cancer, planned fatherhood, recent heart event
Issues with oral test?
BAD bioavailability- take with high fat meal if want SOME effect
Where are androgens made in females?
adrenal glands, some in ovaries and in periphery
Role of androgens in females?
sex function, follicular development
Is testosterone good for females?
no evidence it is useful in any condition
S/e of test in females?
acne, hair,
