BPH Flashcards

1
Q

What is the function of the prostate?

A

add fluid to ejaculate

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2
Q

What tissue of the prostate is sensitive to testosterone?

A

epithelial

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3
Q

What tissue of prostate is sensitive with a1 receptors?

A

stromal

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4
Q

AT what age do most men have BPH?

A

> 70

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5
Q

How does an enlarged prostate occur?

A

androgens converted to DHT= hyperplasia in prostate

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6
Q

If testosterone decreases as we age why do older men get prostate enlargement?

A

more intra-prostatic 5-a- reductase (makes DHT)

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7
Q

Symptoms of BPH?

A

frequency, nocturia, leakage, straining, pain

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8
Q

complications of BPH?

A

incontinence, UTI, renal failure, kidney stones

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9
Q

What test to monitor progression of prostate?

A

PSA

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10
Q

Drugs that exacerbate BPH?

A

androgens, anticholinergics
AD-TCA
Antihistamines
antipsychotics-1st gen
muscle relax
stimulants

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11
Q

Non pharm for BPH?

A

less fluid, caffeine, alcohol
stop smoking
bladder training, active

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12
Q

What alpha blockers are pro selective?

A

alfuzosin, silodosin, tamsulosin

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13
Q

Do Alpha blockers lower PSA?

A

NO

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14
Q

How long for alpha blockers to work?

A

1-2 weeks

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15
Q

s/e of alpha blockers?

A

dizzy, fatigue, headache, IFIS (ocular)

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16
Q

Which alpha blocker causes more IFIS?

A

tamsulosin

17
Q

CI of alpha blockers

A

too hypotensive
HF
3A4 drugs

18
Q

How do dutasteride/finnasteride work?

A

block conversion to DHT

19
Q

Does dutasteride lower PSA?

20
Q

How long for effect of dutasteride/finnasteride?

21
Q

s/e of dutasteride?

A

sex dysfunction
gyno
birth defects in male

22
Q

Does dutasteride reduce prostate cancer?

A

YES but not approved for it

23
Q

Why does tadalafil work for BPH?

A

smooth muscle relaxation will help

24
Q

Why is tadalafil only indicated?

A

long half life

25
Q

Difference in dosing for Cialis for ED vs BPH?

A

daily for BPH

26
Q

Why would we use anticholinergics in BPH?

A

if urgency/frequency
go low go slow

27
Q

what anticholinergics for BPH?

A

oxybutinin, solfenacin, tolterodine

28
Q

What natural health products likely work for BPH?

A

pygeum-helps with nocturia
beta-sitosterol- urinary sx
saw palmetto- NO