Testicular Cancer

Question 1

What are the two major types of germ cell tumors?

Answer 1

seminoma; non-seminoma

Question 2

What does a seminoma secrete?

Answer 2

b-hCG

Question 3

What does a non-seminoma secrete?

Answer 3

b-hCG + a-fetoprotein (aFP)

Question 4

How do most patients present with testicular cancer?

Answer 4

painless testis mass

Question 5

What stage of testicular cancer is classified as metastatic?

Answer 5

Stage III

Question 6

Would you ever do a needle biopsy in the scrotum?

Answer 6

NO

Question 7

What can cause an increase in aFP other than testicular cancer? (2)

Answer 7

hepatocellular carcinoma; cirrhosis

Question 8

What can cause an increase in b-hCG other than testicular cancer? (4)

Answer 8

prostate cancer; bladder cancer; uretal cancer; marijuana use

Question 9

Which is better in terms of curing testicular cancer? Cisplatin or carboplatin?

Answer 9

cisplatin

Question 10

What platinum toxicities can occur late after treatment? (2)

Answer 10

neuropathy; tinnitus

Question 11

What late toxicity is associated with cisplatin?

Answer 11

nephrotoxicity

Question 12

What late toxicity is associated with bleomycin?

Answer 12

pulmonary fibrosis

Question 13

What secondary malignancy is associated with testicular cancer?

Answer 13

leukemia