Chemotherapy Induced Nausea/Vomiting Flashcards
List the complications of nausea/vomiting. (4)
dehydration; electrolyte imbalance; fatigue; depression
Definition: a learned response conditioned by previous emetic reactions to chemotherapy
Anticipatory N/V
Definition: emetic response occuring within 24 hours of receiving chemotherapy
Acute N/V
Definition: emetic response occuring more than 24 hours after last dose of chemotherapy
Delayed N/V
Definition: emetic response that occurs even if taking scheduled anti-emetics prior to chemotherapy
Breakthrough N/V
Definition: nausea/vomitting that persists while on anti-emetic therapy
Refractory N/V
Definition: an inclination to vomit; a feeling in the throat or epigastric region alerting the individual that vomiting may occur
Nausea
Definition: labored movement of abdominal and thoracic muscles before vomitting
Wretching
Definition: the ejection of gastric contents through the mouth
Vomiting
What are the two main targets of anti-emetic medications?
serotonin; substance P
Name a highly emetogenic chemotherapy drug.
cisplatin
List risk factors for chemotherapy induced nausea/vomiting. (6)
female; younger age; history of motion sickness; history of morning sickness; previous CINV; anxiety/anticipation of nausea
Name a factor that can be protective against CINV.
chronic ethanol intake
What are some common toxicities of serotonin antagonists? (3)
headache; prolonged QT interval; constipation
What are some common toxicities of short-term corticosteroids? (3)
insomnia; increased appetite; hyperglycemia