Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Therapeutics IV > Lung Cancer > Flashcards

Lung Cancer Flashcards

1
Q

In what patient population should you consider lung cancer screenings?

A

high risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are some factors that would put a patient at high risk for lung cancer?

A

age 55-74; 30 pack per year history; still smoking or quit in the last 15 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the benefit of smoking cessation in relation to lung cancer?

A

decreases risk of secondary cancers developing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

EFGR mutations predict sensitivity to ____.

A

tyrosine kinase inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

KRAS mutations predict resistance to ____.

A

tyrosine kinase inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

KRAS mutations are exclusive to what patient population?

A

heavy smokers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ROS-1 mutations are present in what patient population?

A

never smoked/light smokers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Do you test for PD-L1 in NSCLC or SCLC?

A

NSCLC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the two most common types of NSCLC?

A

adenocarcinoma; squamous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

NSCLC adenocarcinoma is most common in ____.

A

non-smokers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Squamous NSCLC is clearly related to ____.

A

smoking

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which is more rapidly progressive? NSCLC or SCLC?

A

SCLC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the mainstays of treatment for SCLC?

A

chemotherapy & radiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the mainstay of treatment for NSCLC?

A

surgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What stage of lung cancer do most patients present with?

A

metastatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Definition: tumor is confined to the hemithorax and contained in one radiation port

A

limited stage SCLC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Definition: tumor not confined to the hemithroax, not contained in one radiation port, distant metastasis

A

extensive stage SCLC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the goal of therapy in limited stage SCLC?

A

cure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What chemotherapy regimen is used in limited stage SCLC?

A

cisplatin + etoposide

20
Q

What should be given along with chemotherapy in limited stage SCLC?

A

radiation

21
Q

Does surgery play a role in limited stage SCLC?

A

no

22
Q

What is used to prevent brain metastases in SCLC?

A

prophylactic cranial radiation

23
Q

Is radiation used as curative therapy in extensive stage SCLC?

A

no, just chemotherapy

24
Q

What are the two first line therapies for extensive stage SCLC?

A

atezolizumab + carboplatin + etoposide OR durvalumab + carboplatin + etoposide

25
Q

Is maintenance therapy recommended after chemotherapy cycles are completed in extensive stage SCLC?

A

yes

26
Q

What drugs are used as maintenance therapy for extensive stage SCLC?

A

atezolizumab & durvalumab

27
Q

Which is preferred in SCLC? Cisplatin or carboplatin?

A

cisplatin

28
Q

Why would you choose carboplatin over cisplatin?

A

the patient requires a less toxic therapy

29
Q

What is the preferred regimen in non-squamous NSCLC?

A

cisplatin + pemetrexed

30
Q

What is the preferred regimen in squamous NSCLC?

A

cisplatin + docetaxel OR cisplatin + paclitaxel

31
Q

What maintenance therapy is given to patients with unresectable NSCLC?

A

durvalumab

32
Q

Is treatment considered palliative or curative in unresectable NSCLC?

A

palliative

33
Q

What therapy is available for PD-L1+ patients with unresectable NSCLC?

A

pembrolizumab

34
Q

What is the first line EGFR targeted therapy?

A

osimeritinib

35
Q

What is the first line ALK targeted therapy?

A

alectinib

36
Q

What is the first line ROS-1 targeted therapy?

A

crizotinib

37
Q

What is the first line BRAF targeted therapy? Hint: includes a MEK inhibitor

A

dabrafenib + trametinib

38
Q

What is the first line NTRK gene fusion therapy?

A

larotrectinib

39
Q

What is the first line RET rearrangement therapy?

A

selpercatinib

40
Q

What is the first line MET targeted therapy? (2)

A

capmatinib OR tepotinib

41
Q

What is the first line KRAS targeted therapy?

A

sotorasib

42
Q

What regimen is recommended for patients with mutation negative non-squamous NSCLC?

A

carboplatin + pemetrexed + pembrolizumab

43
Q

What regimen is recommended for patients with mutation negative squamous NSCLC? (immunotherapy is not contraindicated)

A

pembrolizumab + carboplatin + paclitaxel

44
Q

What regimen is recommended for patients with mutation negative squamous NSCLC if immunotherapy is contraindicated?

A

carboplatin + etoposide

45
Q

When would you give a patient albumin-bound paclitaxel instead of regular paclitaxel?

A

if they have a contraidication to steroids

Therapeutics IV (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions