Other Chemotherapy Toxicities

Question 1

List the chemotherapy agents that can cause heart failure. (3)

Answer 1

anthracyclines; HER2 targeted therapy; high dose cyclophosphamide

Question 2

List the chemotherapy agent that can cause pulmonary toxicity. (1)

Answer 2

bleomycin

Question 3

List the chemotherapy agent that can cause hemorrhagic cystitis. (1)

Answer 3

cyclophosphamide

Question 4

What metabolite of cyclophosphamide leads to neurotoxicity?

Answer 4

choloracetaldehyde

Question 5

What metabolite of cyclophosphamide leads to hemorrhagic cystitis?

Answer 5

acrolein

Question 6

What is used to treat neurotoxicity caused by chloroacetaldehyde?

Answer 6

thyamine; methylene base

Question 7

What is used to decrease risk of hemorrhagic cystitis caused by acrolein?

Answer 7

mesna

Question 8

Definition: cardiac dysfunction that occurs immediately after a single dose or course of chemotherapy

Answer 8

Type 1 acute cardiotoxicity

Question 9

Which Type 1 cardiotoxicity is associated with cumulative doses?

Answer 9

chronic

Question 10

Definition: cardiac dysfunction that occurs within a year following anthracycline therapy

Answer 10

Type 1 chronic cardiotoxicity

Question 11

Definition: cardiac dysfunction that develops several years or decades after chemotherapy

Answer 11

Type 1 late-onset cardiotoxicity

Question 12

Who is most likely to experience late-onset cardiotoxicity?

Answer 12

childhood/adolescent cancer survivors who received anthracylines

Question 13

Which two drugs should you never use at the same time due to risk of cardiotoxicity?

Answer 13

trastuzumab & anthracyclines

Question 14

What agent causes Type II cardiotoxicity?

Answer 14

trastuzumab

Question 15

What pathway is involved in Type II cardiotoxicity?

Answer 15

EGFR pathway