Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Blood Bank > Test 4 > Flashcards

Test 4 Flashcards

0
Q

List five antibodies that are IgM antibodies.

A

Anti- Lea, anti-Leb, anti-I, anti-P1, anti-M, anti-N, anti-Lua
Anti-Lewis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

List five antibodies that are IgG antibodies.

A

Anti-K, Anti- Fya, Anti-Fyb, Anti- Jka, Anti-Jkb, anti-S

Anti-kell, anti- Duffy, anti-Kidd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which class of antibody reacts at room temperature but not at 37 degrees Celsius?

A

IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

List four antibodies whose reactivity would show increased agglutination if the screening cells were pre-treated with enzymes (do not include Rh system antibodies).

A

Kell, Kidd

Anti-Jka, anti-Jkb, anti-C, anti-K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

List four antigens that are removed from the red blood cell membrane by enzyme treatment.

A

M, N, Fya, Fyb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

List three antigens that are not expressed on cord blood cells.

A

Lea, Leb, I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which antigen is most immunogenic next to the D antigen?

A

K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is another name for the anti-PP1Pk antibody produced by people with the p genotype?

A

Anti-Tja

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which of these antibodies might be present in a patient who has never been transfused nor pregnant?

a. Anti-Lea
b. Anti-Fya
c. Anti-Jka
d. Anti-N
e. Anti-P1
f. Anti-K
g. Anti-Jsa
h. Anti-S

A

a. Anti-Lea
d. Anti-N
e. Anti-P1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

List two antigens that are made from another antigen.

A

I, Leb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which antibodies are very dangerous because their titers fall rapidly to undetectable levels?

A

Kidd antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which antibody causes paroxysmal cold hemoglobinuria? Is it IgM or IgG?

A

Auto anti-P, IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

If a patient builds an anti-U antibody, which three antigens are not present on their red blood cells?

A

U, S, s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which antigen is associated with Chronic Granulomatous Disease?

A

Kx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

State whether finding compatible blood with the following antibodies would be “easy” or “difficult”
a. Anti-Jsa b. Anti-Kpb c. Anti-K d. Anti-k e. Anti-Fya f. Anti-S g. Anti-s

A

a. Anti-Jsa easy- antigen low incidence
b. Anti-Kpb difficult- antigen high incidence
c. Anti-K easy- antigen low incidence
d. Anti-k difficult- antigen high incidence
e. Anti-Fya easy- antigen low incidence
f. Anti-S easy- antigen low incidence
g. Anti-s easy 10%- antigen low incidence 10%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Describe “dosage” effect.

A

Reaction is going to be stronger with homozygous than heterozygous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which group of antibodies typically give a “mixed field” agglutination pattern in serological testing?

A

Lua and Lub

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What procedure would help distinguish an anti-K and anti-Fya antibody on an Identification Cell Panel?

A

Addition of enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which antibody agglutinates all adult red blood cells but will not agglutinate Group O cord blood cells?

A

Anti-I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

If a patient has the genotype M+N+S-s-, what other antigen is also missing?

A

U antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Which of the following antigens is a low incidence antigen?

a. k (cellano)
b. Kpa (Penny)
c. Kpb (Rautenberg)
d. Jsb (Matthews)

A

B. Kpa (Penny)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

List three common characteristics of IgG blood group antibodies.

A

React at 37 degrees Celsius
Don’t usually activate complement
Cause HDN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Which antigen is missing from the patient’s red blood cells if they have McLeod syndrome?

A

Kx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Which of the following antibodies might cause Hemolytic Disease of the Fetus and Newborn?

a. Anti-Lea
b. Anti-K
c. Anti-N
d. Anti-Fya
e. Anti-P1
f. Anti-s

A

b. Anti-K
d. Anti-Fya
f. Anti-s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
What procedure could you use to identify an anti-I antibody?
Group O cord blood cells
25
Which antibody causes Cold Agglutinin Disease?
I
26
Which antibody is sometimes formed after infection with Mycoplasma pneumoniae?
Anti-I
27
Which antibody is called a “biphasic” antibody? What is another name for this antibody?
Auto anti-P | Donath-Landsteiner
28
Why do we “grade” agglutination reactions?
May show there is two antibodies other 1
29
What procedure can we perform to eliminate interference in the antibody screen or identification panel caused by a cold reacting autoantibody?
Pre-warming
30
Which antibodies causes HDN and HDFN?
IgG
31
Which antibody reacts at 37 degrees (body temp)?
IgG
32
Which antibodies are cold reacting (room temp and below)?
IgM
33
Which antibodies are called clinically insignificant?
IgM
34
How many sets of alleles does the Kell system have and what are they?
3 K and k Kpa and Kpb Jsa and Jsb
35
What is the only antibody that is commonly encountered in the Kell system?
Anti- K
36
Which antigens are low frequency in the Kell system?
Jsa and Kpa
37
Which antigens are high frequency in the Kell system?
Jsb and Kpb
38
K antigen is absent in what percentage of people?
91%
39
Do most patients have the ability to build the antibody for K or do they have the antigen?
Build the antibody | 9% have the antigen
40
What is the most immunogenic antibody next to the D antigen?
Anti- K
41
Is anti- K IgM or IgG?
IgG
42
Does anti-K activate complement?
No
43
Is Kx present is most patients?
Yes
44
How is Kx antigen inherited? (X or Y)
X-linked
45
What can the absences of Kx antigen cause?
McLeod syndrome | Chronic Granulomatous disease
46
What alleles are in the Duffy system?
Fya and Fyb
47
Are the Duffy system antibodies common or rare?
Relatively common
48
What percentage of people can make the Fya antibody?
34%
49
What percentage of people can make the Fyb antibody?
17%
50
Does Fya and Fyb activate complement? And are they IgM or IgG?
No and IgG
51
Can Duffy antigens be removed by enzymes?
Yes
52
What are the Kidd alleles?
Jka and Jkb
53
Are Kidd system antibodies IgM or IgG? Can they activate complement?
IgG and yes
54
Kidd antibodies cause what kind of destruction?
Intravascular and extravascular
55
Which antibody titer can rapidly fall to undetectable levels?
Kidd antibodies | Jka and Jkb
56
What antibody is the major cause of delayed transfusion reaction?
Kidd antibodies | Jkb and Jka
57
Which antibodies are usually produced in association with other antibodies?
Kidd antibodies
58
Which antigen is a newborn negative for at birth but can become positive?
Lewis
59
Which antigens are absorbed onto the red blood cell after birth?
Lewis antigens
60
Are Lewis antigens IgM or IgG
IgM
61
Are Lewis antigens clinically insignificant?
Yes
62
Which antigen can interfere with room temperature ABO reverse grouping, etc.?
Lewis antigen
63
Do Lewis antigens still circulate in body fluids even if you are a nosecretor?
Yes
64
How do you get the I antigen?
From little i | Newborns only get i antigen which converts to I in the first couple years of life
65
What does everyone build to I?
Auto anti-I but it is only reactive at cold temperatures
66
What happen if thermal amplitude rises with auto anti- I?
The anti-I attaches to the patients rbcs and causes cold agglutinin disease
67
What detects the I antibody?
Group O cord blood
68
What antibody can people with P antigen make? Is the antibody IgG or IgM
P1 and IgM | Is clinically insignificant
69
Some people can make auto anti-P antibody, what can it cause?
Paroxysmal cold hemoglobinuria
70
Is auto anti-P IgG or IgM? Does it activate complement?
IgG and yes
71
What is the auto anti-P also called?
Donath- Landsteiner antibody | Bi-phasic
72
What is the anti- PP1PK?
Antibody made by very rare p people who lack the P system antigens
73
Is ANTI- PP1PK IgG or IgM?
IgG
74
Who is p people compatible with?q
Only other p people
75
What is the old name for anti-PP1PK?
Anti-Tja
76
What are anti- M and anti- N IgM or IgG
IgM
77
Anti-S and anti-s are IgG or IgM?
IgG
78
Are M and N removed by enzymes?
Yes
79
U antigen is present in people who have what?
An S or s antigens
80
Is anti- Lua IgG or IgM?
IgM and usually clinically insignificant
81
Anti-Lub is IgG or IgM?
IgG
82
Is Lutheran antibodies rare or common?
Rare
83
Which antibodies have mixed field agglutination?
Lutheran
84
1. Which blood group system possesses the Jsb and Kpa antigens? a. Duffy. c. Kell b. Lutheran. d. Kidd
C
85
2. An antibody commonly associated with delayed transfusion reactions is: a. anti-Lua. c. anti-Jkb b. anti-S. d. anti-M
C
86
3. Which phenotype is associated with a resistance to malarial invasion? a. Fy(a−b−). c. Le(a−b−) b. Jk(a−b−). d. Lu(a−b−)
A
87
4. Enzyme-treated reagent red cells used in antibody identification enhances all of the following antibodies except: a. anti-M. c. anti-Jkb b. anti-Lea. d. anti-C
A
88
5. Which of these antibodies are typically IgM? a. anti-K. e. anti-Leb b. anti-S. f. anti-Jkb c. anti-U. g. anti-P1 d. anti-N
D E G
89
6. Which of the following reagents destroys the Kell system antigens? a. ficin. c. PEG b. albumin. d. DTT
D
90
7. Glycophorin A and glycophorin B possess antigen sites for which blood group system? a. Duffy. c. Lewis b. Kidd. d. MNS
D
91
8. Select the antibody that is characteristically clinically insignificant: a. anti-Kpb. c. anti-Leb b. anti-S. d. anti-Fya
C
92
9. The McLeod phenotype is associated with: a. Rhnull phenotype. c. U-negative phenotype b. K0 phenotype. d. absence of Kx antigens
D
93
10. Typing as Lu(a−b−) would be considered: a. rare in whites but not blacks. c. rare in all populations b. rare in blacks but not whites. d. common in all populations
C
94
11. Cold autoantibodies are usually of which specificity? a. I. c. P1 b. M. d. S
A
95
12. Individuals with the p phenotype can make: a. anti-P2. c. anti-P b. anti-p. d. anti-Tja
D
96
13. Alleles within the Lewis system include: a. Le, le. c. Le, Se, H b. Lea, Leb. d. Le, Le
A
97
14. Which of the following antibodies requires the antiglobulin test for in vitro detection? a. anti-M. c. anti-U b. anti-P1. d. anti-I
C
98
15. What procedure would help to distinguish between an anti-Fya and anti-Jka in an antibody mixture? a. lowering the pH of the patient's serum b. using a thiol reagent c. running an antibody identification panel d. running a ficin-treated panel
D
99
16. Anti-K1: a. agglutinates IATs b. is usually of the IgM antibody class c. does not agglutinate with K+k+ panel cells d. loses reactivity in enzyme phases
A
100
17. Which of the following antigens is poorly expressed on cord blood cells? a. K1. c. Leb b. M. d. D
C
101
18. Reagent antibody screening cells may not detect antibodies directed against low-incidence antigens. Which antibody is most likely to go undetected? a. Vel. c. Kpa b. S. d. K
C
102
19. Select the disease commonly associated with the McLeod phenotype: a. infectious mononucleosis. c. Hodgkin's disease b. chronic granulomatous disease. d. PCH
B
103
20. Which set of antibodies could you possibly find in a patient with no history of transfusion or pregnancy? a. anti-I, anti-S, and anti-P. c. anti-A, anti-I, and anti-D b. anti-M, anti-c, and anti-B. d. anti-B, anti-I, and anti-Lea
D

Blood Bank (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions