TEST 3 - ANTINEOPLASTIC DRUGS - DEFINITIONS Flashcards
Uncontrolled and rapid cellular growth
CANCER
Grow & invade adjacent tissues
CANCER CELLS
Break away from original tumor mass and travel by means of the blood or lymphatic system to distant sites
CANCER CELLS
is a disease or symptom that is the consequence of the presence of cancer in the body?
PARANEOPLASTIC SYNDROMES (PNS)
WHAT ARE THE First Sign of Malignancy:
o Cachexia (most common) – like wasting
o Fever, fatigue, weight loss
o Others
WHAT IS THE Pharmacological treatment of cancer?
CHEMOTHERAPY
Uses Antineoplastic drugs (like anticancer)
2 groups of antineoplastic drugs (based on where they work in the cellular life cycle)
Cell cycle-nonspecific (CCNS)
Cell cycle-specific (CCS)
o Some drugs have characteristics of both
CHEMOTHERAPY
TRUE OR FALSE
Does Antineoplastic drugs differentiate between healthy and non-cancerous cells
FALSE
Original site of growth
PRIMARY LESION
- Uncontrolled cell growth
* Secondary lesion in a new part of the body
METASTASIS
Mass of new cells; tumor
NEOPLASM
can be benign or malignant (cancerous)
TUMOR
cancers of epithelial tissue
CARCINOMAS
cancers of connective tissue
SARCOMA
cancers of bone marrow, lymph tissue
LYMPHOMAS
cancer cancers of blood
LEUKEMIAS
Non-cancerous and not an immediate threat to life.
BENIGN
Leakage of an intravenously or intra-arterially administered drug into the tissue space surrounding the blood vessel.
EXTRAVASATION
The absence of cellular differentiation
ANAPLASIA
A malignant neoplasm of blood-forming tissues.
LEUKEMIA
A neoplasm of lymphoid tissue that is usually malignant but, in rare cases, may be benign
LYMPHOMA
The process by which cancer spreads from the original site of growth to a new and remote part of the body.
METASTASIS
Antineoplastic drugs that are cytotoxic in any phase of the cellular growth cycle.
CELL-CYCLE NON-SPECIFIC
A malignant neoplasm of the connective tissue arising in fibrous, fatty, muscular, synovial, vascular, or neural tissue.
SARCOMA
A permanent change in cellular genetic material (DNA).
MUTATION
An alkylating agent.
CYCLOPHOSPHAMIDE
A cytotoxic antibiotic.
BLEOMYCIN
An antimetabolite.
METHOTREXATE
A mitotic inhibitor.
VINCRISTINE
A radiopharmaceutical.
SODIUM IODIDE I-131
The lowest point in a fluctuating value.
NADIR
