TERTIARY STRUCTURE

Question 1

WHAT HAPPENS DURING THE TERTIARY STRUCTURE?

Answer 1

FURTHER FOLDING OF THE POLYPEPTIDE TO GIVE IT A SPECIFIC 3D SHAPE

Question 2

WHAT BONDS ARE FORMED DURING THE TERTIARY STRUCTURE?

Answer 2

• HYDROGEN BONDS
• IONIC BONDS
• DISULPHIDE BONDS (SULFUR)
• HYDROPHOBIC INTERACTIONS

Question 3

HOW DOES A CHANGE IN THEPRIMARY STRUCTURE AFFECT THE TERTIARY STRUCTURE?

Answer 3

• DIFFERENT AMINO ACIDS SEQUENCE = DIFFERENT R GROUPS
• BONDS BETWEEN R GROUPS FORM IN DIFFERENT PLACES / DIFFERENT R GROUPS
• 3D SHAPE / TERTIARY STRUCTURE IS DIFFERENT

Question 4

WHEN DOES THE TERTIARY STRUCTURE FORM?

Answer 4

WHEN THE A-HELIX OR B-PLEATED SHEETS COIL OR FOLD UP (MORE BONDS FORM BETWEEN DIFFERENT AMINO ACIDS)

Question 5

WHAT 3 BONDS CAN FORM WHEN THE STRUCTURE CHANGES?

Answer 5

• HYDROGEN BONDS
• IONIS BONDS
• DISULPHIDE BONDS

Question 6

WHERE COULD HYDROGEN BONDS FORM DUE TO THE STRUCTURAL CHANGE?

Answer 6

BETWEEN PARTIALY + AND - CHARGES IN DIFFERENT R GROUPS

Question 7

HOW COULD IONIC BONDS FORM DUE TO A CHANGE IN STRUCTURE?

Answer 7

IF AN R GROUP IS NEGATIVELY CHARGED, IT CAN IONICALLY BOND TO A + CHARGED R GROUP

Question 8

HOW COULD DISULPHIDE BONDS FORM DUE TO A CHANGE IN STRUCTURE?

Answer 8

R GROUPS COULD CONTAIN A SULFUR ATOM = COULD BOND TO SULFUR ATOMS IN THE R GROUP OF ANOTHER AMINO ACID

Question 9

WHAT ELSE COULD HAPPEN DURING THE CHANGE IN STRUCTURE AS WELL AS BOND CHANGES?

Answer 9

COULD BE INTERACTIONS BETWEEN HYDROPHOBIC AND HYDROPHILIC REGIONS OF THE POLYPEPTIDE CHAIN

Question 10

WHAT DO HYDROPHOBIC R GROUPS DO?

Answer 10

CLUMP TOGETHER ON THE INSIDE OF THE PROTEIN (AWAY FROM WATER)

Question 11

WHAT DO HYDROPHILIC R GROUPS DO?

Answer 11

THEY’RE PUSHED TO THE OUTSIDE AS THEY ARE ATTRACTED TO WATER