Term 2 Flashcards

1
Q

Nervous System

A

Controls homeostasis through nerve impulses (action potentials) conducted along axons of neurons. At axon terminals, impulses trigger release of neurotransmitter molecules. The result is either excitation or inhibition of specific other neurons, muscle fibers (cells), or gland cells.

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2
Q

Nervous System

Types of cells of the nervous system

A

Neurons( Nerve cells) Neuroglia

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3
Q

Nervous System

Neurons (nerve cells) properties

A

Excitability: ability to RESPOND to a stimulus

Conductivity: ability to TRANSMIT a signal

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4
Q

Nervous System

Neuroglia properties

A

Specialized cells that support the neurons in some way

Ex. They phagocytize foreign substances, produce cerebrospinal fluid, and form myelin sheaths around axons

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5
Q

Nervous System organization

A

Central nervous system (CNS)

Peripheral nervous system (PNS)

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6
Q

Nervous system organization

Central nervous system (CNS)

A

Consists of the brain & spinal cord which are surrounded and protected by the skull and vertebral column respectively

May be thought of as the central control center of the body, receiving and interpreting or integrating all stimuli and relaying nerve impulses to muscles and glands where the designated actions take place

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7
Q

Nervous system organization

Peripheral nervous system

A

Includes all of the neural tissue outside the CNS. it delivers sensory information to the CNS and carries motor commands to peripheral tissues and systems.

Somatic nervous system (SNS)

Automatic (autonomic) nervous system (ANS)

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8
Q

Nervous system organization

Peripheral nervous system

Somatic nervous system

A

Division of the PNS composed of:

Somatic Afferent SENSORY division - which receives sensory information and conveys it to the spinal cord and brain via nerves.

Somatic Efferent MOTOR division - which regulates the contraction of skeleton via neuronal pathways that descend from the brain and spinal cord to lower motor neurons

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9
Q

Nervous system organization

Peripheral nervous system

Autonomic nervous system

A

Consists of sensory neurons that convey information from receptors in the viscera to the CNS and motor neurons from the CNS that conduct impulses to smooth muscle, cardiac muscle, and glands. Since its motor responses are not normally under conscious control, the ANS is involuntary.

Motor portion: sympathetic and parasympathetic division. With a few exceptions, the viscera receives instructions from both.

Sympathetic neurons - involve expenditure of energy

Parasympathetic neurons - restore and conserve body energy

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10
Q

Nervous System

Neurons - Three principled parts

A

The cell body

Dendrites

An axon

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11
Q

Nervous System

Neurons

Cell body

A

Vary in shape and size Has a large nucleus which contains a nucleolus, as well as several structures that are responsible for metabolism, growth and repair of the neuron - endoplasmic reticulum, lysosomes, mitochondria, neurofilaments, neurotubules, and Golgi apparatus

Neurofilaments: provide a skeletal framework for the axon

Neurotubules: function in the intracellular transport of the proteins and other substances, in both directions between the cell body and the ends of the processes

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12
Q

Nervous System

Neurons

Dendrites

A

Thread-like projections which are actually extensions of the cell body

Conduct nerve impulses towards the cell body

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13
Q

Nervous System

Neurons

Axons

A

A neuron generally has just one axon which extends from the cell body Carries nerve impulses away from the cell body to the next neuron, muscle or gland

Originates from the AXON HILLOCK

The initial segment, the site where the nerve impulse is initiated, lies immediately after the axon hillock

May have side processes called COLLATERAL BRANCHES end in a spray of small axon branches or TELODENRIA which end I tiny swellings called end bulbs

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14
Q

Nervous System

Neurons

Synapse

A

The junction between the end bulb of one axon and the cell body, dendrite, or axon of another neuron

A site where information is transferred from one cell to another

Ex. Neuron, muscle,gland

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15
Q

Nervous System

Neurons

Neurolemmocyte

A

Schwann cells

Form myelin sheaths around axons in the PNS

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16
Q

Nervous System

Neurons

Oligodendryte

A

Form myelin sheaths in the CNS

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17
Q

Nervous System

Myelination of axons

A

Some axons are covered with layers of a lipid sheath called myelin

Myelin sheath is formed by specialized non-neural cells called SCHWANN CELLS in the PNS and OLIGODENROCYTES in the CNS

The outer layer, or sheath, of the cells is the NEUILEMMA sheath

A myelin sheath is segmented, interrupted at regular intervals by gaps called NODES OF RANVIER. The distance between nodes is the INTERNODE.

There are myelinated and unmyelinated axons

A myelinated nerve fiber transmits a nerve impulse faster

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18
Q

Nervous System

Types of Neurons - Structural Classification

Multipolar Neurons

A

Have many processes consisting of many dendrites and a single axon

Ex. association (interneurons) and motor neurons

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19
Q

Nervous System

Types of Neurons - Structural Classification

Bipolar Neurons

A

have two processes: a dendrite and an axon which conducts action potentials to the CNS

Sensory neurons

Relatively Rare but play an important role in relaying information concerning sight, smell, and hearing

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20
Q

Nervous System

Types of Neurons - Structural Classification

Unipolar Neurons

A

Have one process, an axon Most sensory neurons are unipolar

Their peripheral ends have dendrite-like processes that respond to stimuli, producing action potentials that are conducted by the axon to the CNS

The branch that extends from the periphery to the neuron cell body, conducts action potentials to the cell body. According to a functional definition of a dendrite, it could be classified as a dendrite

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21
Q

Nervous System

The Reflex Arc - Location

Afferent Neurons

A

Convey information from the tissues and organs of the body to the CNS

Unipolar neurons are the most common in the PNS

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22
Q

Nervous System

The Reflex Arc - Location

Efferent or Motor Neurons

A

Convey nerve impulses away from the CNS to effectors (muscles and glands)

All motor neurons that control skeletal muscles are multipolar neurons

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23
Q

Nervous System

The Reflex Arc - Location

Interneurons (Association) Neurons

A

Lie between sensory and motor neurons in the neural pathways of the CNS

Responsible for the distribution of sensory information and the coordination of motor activity

Multipolar neurons

24
Q

Endocrine System

A

Releases its messenger molecules, called hormones into the bloodstream. The cardiovascular system then delivers hormones to virtually all cells throughout the body

25
Q

Nervous VS Endocrine

The __ system causes muscles to contract and glands to secrete their product

VS

The __ system alters metabolic activities, regulate growth and development, and guides reproductive processes.

A

The NERVOUS system causes muscles to contract and glands to secrete their product

The ENDOCRINE system alters metabolic activities, regulate growth and development, and guides reproductive processes.

26
Q

Nervous VS Endocrine

__ most often produce their effects within a few milliseconds.

__ generally take several hours to bring about their responses.

A

NERVE IMPULSES most often produce their effects within a few milliseconds.

HORMONES generally take several hours to bring about their responses.

27
Q

Nervous VS Endocrine

The effects of activating the __ system are generally briefer than the effects produced by the __ system

A

The effects of activating the NERVOUS system are generally briefer than the effects produced by the ENDOCRINE system

28
Q

Endocrine System organization

A

Endocrine glands

Exocrine glands

29
Q

Endocrine System organization

Endocrine Glands

A

Endocrine glands and specific cells are ductless, secreting products called hormones into extracellular spaces from which they enter the blood stream and circulate throughout the body to their target areas

30
Q

Endocrine System organization

Exocrin glands

A

Exocrine gland secretions, such as sweat and salivary glands, empty directly into ducts that transport them to specific locations

31
Q

Endocrine System

Hormones

A

Specialized chemical substances produced and secreted by an endocrine cell or organ

Effective only at specific target cells

Like neurotransmitters, they influence their target cells by chemically binding to integral proteins or glycoprotein molecules called receptors

32
Q

Endocrine System

Hormones

Circulating

A

Hormones that can pass into the blood and act on distant target cells ENDOCRINES

33
Q

Endocrine System

Hormones

Local

A

Hormones that act locally without first entering the bloodstream.

PARACRINES act on neighboring cells

AUTOCRINES act on the same cell that secreted them

34
Q

Endocrine System

Chemical Signal Classification

Autocrines

A

Released by cells and have a local effect on the same cell that released it

35
Q

Endocrine System

Chemical Signal Classification

Paracrine

A

Released by cells and affect other cell types locally without being transported in the blood

36
Q

Endocrine System

Chemical Signal Classification

Hormone

A

Secreted into the blood to reach their target

37
Q

Endocrine System

Chemical Signal Classification

Neurohormone

A

Produced by neurons and function like hormones

38
Q

Endocrine System

Chemical Signal Classification

Neurotransmitter

A

Released by neurons at a synapse and influences a postsynaptic cell

39
Q

Endocrine System

Chemical Signal Classification

Pheromone

A

A chemical signal secreted into the environment that modify the behavior of other individuals

40
Q

Endocrine System

Chemical Signal Classification

Autocrine example

A

Prostaglandins

41
Q

Endocrine System

Chemical Signal Classification

Paracrine examples

A

Histamine prostaglandins

42
Q

Endocrine System

Chemical Signal Classification

Hormone examples

A

Thyroxine

Insulin

43
Q

Endocrine System

Chemical Signal Classification

Neurohormone example

A

Oxytocin

Antidiuretic hormone

44
Q

Endocrine System

Chemical Signal Classification

Neurotransmitter/neurohumor example

A

Acetylcholine

Epinepherine

45
Q

Endocrine System

Chemical Signal Classification

Pheromones example

A

Sex pheromones are released by humans and many other animals. they are released in the urine of animals, such as dogs and cats. Pheromones produced by women influence the length of the menstrual cycle of other women

46
Q

Endocrine System

Chemical Classification

A

Amines

Polypeptides and Proteins

Steroids

Ecosanoids

47
Q

Endocrine System

Chemical Classification

Amines

A

Hormones derived from the amino acids Tyrosine and Tryptophan.

They include hormones secreted by the adrenal medulla and thyroid

Ex. Epinephrine, thyroid hormones, serotonin

48
Q

Endocrine System

Chemical Classification

Polypeptides and Proteins

A

Consist of chains of amino acids

Synthesized on rough endoplasmic reticulum and exported from the cell

Ex. Insulin (pancreas), erythropoietin (kidney), antidiuretic hormone (posterior pituitary)

49
Q

Endocrine System

Chemical Classification

Steroids

A

Lipids derived from cholesterol

Ex. Testosterone, progesterone, estrogens and cortisol

50
Q

Endocrine System

Chemical Classification

Ecosanoids

A

Derived from arachidonic acid, a fatty acid

Exert control over many body systems

Ex. Thromboxane A2 is made by platelets. it causes vasoconstriction and promotes platelet aggregation. these actions prevent excessive blood loss when a blood vessel is damaged or severed

51
Q

Endocrine System

Hormone Transport in Blood

Water-soluble

A

Catecholamines, peptide, and protein hormones are water-soluble hormones They circulate in watery blood plasma, and in free form (not attached to plasma proteins)

52
Q

Endocrine System

Hormone Transport in Blood

Steroid and Thyroid

A

On entering the blood, steroid and thyroid hormones attache to specific transport proteins, which are synthesized by the liver.

The (shuttle) proteins have 3 functions

  1. they improve the transportability of the lipid-soluble hormones by making them temporarily water-soluble
  2. retard passage of the small hormone molecules through the filtering mechanisms in the kidney, thus slowing the rate of hormone loss in the urine
  3. provide a ready reserve of hormones already present in the bloodstream
53
Q

Endocrine System

Mechanism of Action

Water-soluble

A

Peptides, proteins, and catecholamines (water-soluble hormones) exert at least some of their physiological responses through the increased synthesis of cAMP. These include anitidiuretic hormone (ADH), oxytocin (OT), calcitonin (CT), epinepherine, and norepinephrine

Besides cAMP, several other substances are known as second messengers. These include calcium ions (Ca2+), cyclic guanosine monophate (cGMP), inositol trisphosphate (IP3) and diacylglycerol (DAG)

The hormonal mechanism called the FIXED-MEMBRANE-RECEPTOR MECHANISM, involves the formation of second messengers

54
Q

Endocrine System

Mechanism of Action

Water-soluble

Fixed-Membrane-Receptor Mechanism

A

Catecholamines, peptides, and proteins hormones are water-soluble. their receptors are integral proteins on the plasma membrane of target cells

Since these hormones can deliver their message only to the plasma membrane, they are called FIRST MESSENGER.

a SECOND MESSENGER, commonly cyclic (cAMP), is needed to relay the message inside the cell where hormone-stimulated response can take place. cAMP is synthesized from ATP by adenylate cyclase, an enzyme attached to the inner surface of hte plasma membrane.

cAMP and other second messengers alter cell function in specific ways.

Ex. elevated cAMP increses cardiac muscle contraction

55
Q

Endocrine System

Mechanism of Action

Lipid-soluble (Steroid and Thyroid)

A

Because steroid hormones are lipid-soluble and pass easily through the plasma membrane, their receptors are inside the target cells. The hormone mechanism called the MOBILE-RECEPTOR MECHANISM, involves stimulus of protein synthesis.

Cortisol, aldosterone, thyroid hormones, testosterone, estrogen and progesterone are mobile-receptor hormones and have their receptor hormones and have their receptors localized in the cytoplasm

All other hormones usually use the fixed-membrane-receptor mechanism

56
Q

Endocrine System

Control of Secretion

Negative Feedback Mechanism

A

A hormone is release in response to a specific stimulus and usually, its action reverses or negates the stimulus through a negative feedback mechanism

Ex. control of insulin secretion by blood glucose levels

57
Q

Endocrine System

Control of Secretion

Positive Feedback Mechanism

A

The effect of a positive feedback mechanism is amplification of the stimulus and increasing release of the hormone until a particular process in complete and the stimulus ceases.

Ex. during child birth, the hormone oxytocin stimulates contraction of the uterus. uterine contractions, in turn, stimule more oxytocin release.