Teratogens

Question 1

If a teratogen is given at day 36, what might it cause?

Answer 1

cleft lip

Question 2

If a teratogen is given at day 84, what might it cause?

Answer 2

hypospadius

Question 3

If a teratogen is given at <20 days what might it cause?

Answer 3

limb defects

Question 4

If a teratogen is given at day 20, what might it cause?

Answer 4

anencephaly

Question 5

If a teratogen is given at day 34 what might it cause?

Answer 5

transposition of the great arteries

Question 6

What does phenytoin cause?

Answer 6

neural tube defects

Question 7

What does ramipril cause?

Answer 7

fetal renal failure, oligohydramnios, skull defects

Question 8

What does warfarin cause?

Answer 8

fetal facial/nasal/axial skeleton abnormalities, cardiac abnormalities and learning difficulties

Question 9

What does danazol cause?

Answer 9

virilization of female fetal genitals

Question 10

Features of fetal alcohol syndrome

Answer 10

small head, short stature, poor growth, small eyes, smooth philtrum, thin upper lip, learning difficulties, seizure

Question 11

Which group of antibiotics cause yellowing of neonatal teeth?

Answer 11

tetracycines like lymecyline

Question 12

What do Ace inhibitors and ARBs cause?

Answer 12

renal dysgenesis, oligohydramnios, fetal anuric, pulmonary hypoplasia

Question 13

What does metronidazole cause?

Answer 13

neonatal diarrhoea and lactose intolerance

Question 14

What do aminoglycosides (gent and erythromicin cause)?

Answer 14

ototoxicity

Question 15

What does lithium cause?

Answer 15

cardiac defects

Question 16

What kind of drug is carbimazole?

Answer 16

pro-drug used in treatment of hyperthyroidism

inhibits thyroid peroxidase

Question 17

What does carbimazole cause?

Answer 17

choanal atresia (blocked back of nasal cavity)
GI defects like omphalocele
aplasia cutis (skin missing on the scalp)