Gynaecology drugs

Question 1

What is clomifene used for?

Answer 1

treatment of subfertility in PCOS

Question 2

What does clomifene do?

Answer 2

It is a selective estragen receptor modulator that inhibits oestrogen receptors in the hypothalamus providing negative feedback on gonadotrophin release causing increased FSH and LH helping increase oestrogen production and follicle development and eventually ovulation

Question 3

When does ovulation occur after clomifene?

Answer 3

Typically 6-7 days after the course

Question 4

What are the indications for tamoxifen?

Answer 4

anovulatory infertility and oestrogen receptor positive breast cancer

Question 5

Which cancer does tamoxifen increase the risk of?

Answer 5

Endometrial

Question 6

What kind of drug is tamoxifen?

Answer 6

Selective Estragen receptor modulator (like clomifene)

Question 7

What kind of drug is ullipristal?

Answer 7

Selective progesterone receptor modulator

Question 8

What kind of drug is clomifene?

Answer 8

selective oestrogen receptor modulator

Question 9

What is the mechanism of action for mefanamic acid?

Answer 9

NSAID -inhbits COX and therefore prostaglandin synthesis - used for menstrual pain and bleeding

Question 10

What is the mechanism of action for tranexamic acid?

Answer 10

inhibits plasminogen activator so that plasmin isn’t converted to plasminogen and doesn’t break down clots