teratogens Flashcards
ACEI
renal damage
alkylating agents
absence of digits
multiple anomalies
aminoglycosides
CN VIII toxicity
carbamazepine
facial dysmorphism
developmental delay
neural tube defects
diethylstillbestrol (DES)
vaginal clear cell adenocarcinoma
congenital mullerian anomalies
folate antagonists
neural tube defects
isotretinoin
multiple severe birth defects
lithium
ebstein anomaly
methimazole
aplasia cutis congenita
phenytoin
fetal hydantoin syndrome - cleft palate, cardiac defects, phalanx/fingernail hypoplasia
tetracyclines
discolored teeth
thalidomide
limb defects (phocomelia, micromelia)
valproate
(-) maternal folate absorption –> neural tube defects
warfarin
bone deformities
fetal hemorrhage
abortion
ophthalmologic abnormalities
alcohol
birth defects
intellectual disability
fetal alcohol syndrome
cocaine
abnml fetal growth
fetal addiction
placental abruption
smoking
low birth weight preterm labor placental problems IUGR ADHD
iodine (lack or excess)
congenital goiter or hypothyroidism (cretinism)
maternal diabetes
caudal regression syndrome
congenital heart defects
neural tube defects
vitamin A excess
extremely high risk for spontaneous abortions, & birth defects (cleft palate, cardiac)
X-rays
microcephaly
intellectual disability
