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Pharm > teratogens > Flashcards

teratogens Flashcards

1
Q

ACEI

A

renal damage

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2
Q

alkylating agents

A

absence of digits

multiple anomalies

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3
Q

aminoglycosides

A

CN VIII toxicity

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4
Q

carbamazepine

A

facial dysmorphism
developmental delay
neural tube defects

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5
Q

diethylstillbestrol (DES)

A

vaginal clear cell adenocarcinoma

congenital mullerian anomalies

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6
Q

folate antagonists

A

neural tube defects

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7
Q

isotretinoin

A

multiple severe birth defects

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8
Q

lithium

A

ebstein anomaly

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9
Q

methimazole

A

aplasia cutis congenita

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10
Q

phenytoin

A

fetal hydantoin syndrome - cleft palate, cardiac defects, phalanx/fingernail hypoplasia

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11
Q

tetracyclines

A

discolored teeth

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12
Q

thalidomide

A

limb defects (phocomelia, micromelia)

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13
Q

valproate

A

(-) maternal folate absorption –> neural tube defects

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14
Q

warfarin

A

bone deformities
fetal hemorrhage
abortion
ophthalmologic abnormalities

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15
Q

alcohol

A

birth defects
intellectual disability
fetal alcohol syndrome

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16
Q

cocaine

A

abnml fetal growth
fetal addiction
placental abruption

17
Q

smoking

A 
low birth weight 
preterm labor 
placental problems 
IUGR
ADHD
18
Q

iodine (lack or excess)

A

congenital goiter or hypothyroidism (cretinism)

19
Q

maternal diabetes

A

caudal regression syndrome
congenital heart defects
neural tube defects

20
Q

vitamin A excess

A

extremely high risk for spontaneous abortions, & birth defects (cleft palate, cardiac)

21
Q

X-rays

A

microcephaly

intellectual disability

Pharm (8 decks)

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