drug reactions

Question 1

coronary vasospasm

Answer 1

cocaine
sumatriptan
ergot alkaloids

Question 2

cutaneous flushing

Answer 2

vancomycin
adenosine
niacin
Ca channel blockers

Question 3

dilated cardiomyopathy

Answer 3

anthracyclines - doxorubicin, daunorubicin

dexrazoxane

Question 4

torsades de pointes

Answer 4

class III antiarrhythmics - sotalol 
class IA antiarrhythmics - quinidine 
macrolides
antipsychotics
TCAs

Question 5

adrenalcortical insufficiency

Answer 5

HPA suppression secondary to glucocorticoid withdrawl

Question 6

hot flashes

Answer 6

tamoxifen

clomiphene

Question 7

hyperglycemia

Answer 7

tacrolimus 
protease inhibitors 
niacin 
HCTZ
corticosteroids

Question 8

hypothyroidism

Answer 8

lithium
amiodarone
sulfonamides

Question 9

acute cholestatic hepatitis, jaundice

Answer 9

erythromycin

Question 10

diarrhea

Answer 10

metformin 
erythromycin 
colchicine 
orlistat
acarbose

Question 11

hepatic necrosis

Answer 11

halothane
amanita phalloides
valproic acid
acetaminophen

Question 12

hepatitis

Answer 12

rifampin 
isoniazid 
pyrazinamide
statins 
fibrates

Question 13

pancreatitis

Answer 13

didanosine
corticosteroids 
alcohol
valproic acid 
azathioprine
diuretics (furosemide, HCTZ)

Question 14

pseudomembranous colitis

Answer 14

clindamycin
ampicillin
cephalosporins

Question 15

agranulocytosis

Answer 15

ganciclovir 
clozapine 
carbamazapine 
colchicine 
methimazole 
propylthiouracil

Question 16

aplastic anemia

Answer 16

carbamazepine 
methimazole 
NSAIDs 
benzene 
chloramphenicol
propylthiouracil

Question 17

direct coombs positive hemolytic anemia

Answer 17

methyldopa

penicillin

Question 18

gray baby syndrome

Answer 18

chloramphenicol

Question 19

hemolysis in G6PD deficiency

Answer 19

isoniazid 
sulfonamides 
dapsone 
primaquine 
aspirin
ibuprofen 
nitrofurantoin

Question 20

megaloblastic anemia

Answer 20

phenytoin
methotrexate
sulfa drugs

Question 21

thrombocytopenia

Answer 21

heparin

Question 22

thrombotic complications

Answer 22

OCPs

HRT

Question 23

fat redistribution

Answer 23

protease inhibitors

glucocorticoids

Question 24

gingival hyperplasia

Answer 24

phenytoin
Ca channel blockers
cyclosporine

Question 25

hyperuricemia

Answer 25

``` pyrazinamide thiazides furosemide niacin cyclosporine ```

Question 26

myopathy

Answer 26

``` fibrates niacin colchicine hydroxychloroquine IFNa penicillamine statins glucocorticoids ```

Question 27

osteoporosis

Answer 27

corticosteroids | heparin

Question 28

SLE-like syndrome

Answer 28

``` sulfa drugs hydralazine isoniazid procainamide phenytoin etanercept ```

Question 29

teeth discoloration

Answer 29

tetracycline

Question 30

photosensitivity

Answer 30

sulfonamides amiodarone tetracyclines

Question 31

tendonitis, tendon rupture, cartilage damage

Answer 31

fluoroquinolones

Question 32

cinchonism

Answer 32

quinidine | quinine

Question 33

parkinson-like syndrome

Answer 33

antipsychotics reserpine metoclopramide

Question 34

seizures

Answer 34

isoniazid bupropion imipenem / cislastatin enflurane

Question 35

tardive dyskinesia

Answer 35

antipsychotics | metoclopramide

Question 36

diabetes insipidus

Answer 36

lithium | demeclocycline

Question 37

fanconi syndrome

Answer 37

expired tetracyclines

Question 38

hemorrhagic cystitis

Answer 38

cyclophosphamide | ifosfamide

Question 39

interstitial nephritis

Answer 39

methicilin NSAIDs furosemide

Question 40

SIADH

Answer 40

carbamezepine cyclophosphamide SSRIs

Question 41

dry cough

Answer 41

ACEI

Question 42

pulmonary fibrosis

Answer 42

bleomycin amiodarone busulfan methotrexate

Question 43

antimuscarinic

Answer 43

atropine TCAs H1 blockers antipsychotics

Question 44

disulfiram-like rxn

Answer 44

``` metronidazole certain cephalosporins griseofulvin procarbazine 1st generation sulfonylureas ```

Question 45

nephrotoxicity, ototoxicity

Answer 45

aminoglycosides vancomycin loop diuretics cisplatin

Question 46

CYP inducers

Answer 46

``` chronic alcohol st johns wort phenytoin phenobarbital nevirapine rifampin griseofulvin carbamazepine ```

Question 47

CYP inhibitors

Answer 47

``` acute alcohol ritonavir amiodarone cimetidine ketoconazole sulfonamides isoniazid grapefruit juice quinidine macrolides ```