Teratogens Flashcards
ACEI
renal damage
Alkylating Agent
absence of digits, multiple anomalies
Aminoglycosides
CN VIII toxicity
Carbamazepine
neural tube defect, craniofacial defects, fingernail hypoplasia, developmental delay, IUGR
DES
vaginal clear cell adenocarcinoma, congenital Mullerian anomalies
Folate Antagonist
neural tube defects, abortive if early
Lithium
Ebstein anomaly (atrialized RV)
Methimazole
aplasia cutis congenita
Phenytoin
Fetal Hydantoin Syndrome: microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, intellectual disability
Tetracyclines
discolored teeth
Thalidomide
limb defects (phocomelia, micromelia, flipper limbs)
Valproate
inhibition of maternal folate absorption -> neural tube defects
Warfarin
bone deformities, fetal hemorrhage, abortion, ophthalmological, abnormalities
Fetal Alcohol Syndrome
MC of birth defects and intellectual disability
postnatal developmental retardation, microcephaly, holoprosencephaly, facial abnormalities (smooth philtrum, thin upper lip, small palpebral fissure, hypertelorism), limb dislocaiton, heart defects
Cocaine
abnormal fetal growth, fetal addiction, placental abruption
