Teratogenic Effects

Question 1

Phocomelia is reffered as

Answer 1

Seal limb deformity

Question 2

3 stages in which fetal defects acn occur

Answer 2

Fertilization and implantation(0-17day)
Organogenesis(18-55day)
Growth and development(56- gestation)

Question 3

Ace inhibitors cause

Answer 3

Hypoplasia of organs

Question 4

Nsaids cause

Answer 4

Premature closure of ductus arteriosus

Question 5

Androgens cause

Answer 5

Masculanization of female foetus

Question 6

Progestins cause

Answer 6

Masculanization of female foetus

Question 7

Anthyroids drugs lead to

Answer 7

Foetal goiter

Question 8

Lithium administration cause

Answer 8

Foetal goiter

Question 9

Alcohol intake lead to

Answer 9

Low IQ
Growth retardation
Fetal alcohol syndrome

Question 10

Cancer therapy causes

Answer 10

Cleft palate
Hydrocephalus
Foetal death

Question 11

Sodium valproate cause defects such as

Answer 11

Spina bifida
Neural tube defects
Heart limb deformities

Question 12

Indomethacin/aspirin

Answer 12

Patent ductis arteriosus

Question 13

Tetracyclin

Answer 13

Discoloured deformed teeth

Retard bone growth

Question 14

Hypoplastic phalanges
Cleft lip/palate
Microcephaly
Are causes for

Answer 14

Phenytoin

Question 15

Phocomelia

Defects of internal organs

Answer 15

Thalidomide related teratogenicity

Question 16

US-FDA category of grading birth defects

Answer 16

A (safe)
B
C
D
X (containdicated)

Question 17

Neiral tube defects can be decreased by administration of

Answer 17

Folic acid therapy

Question 18

A possible teratogenic complication of Methimazole.

Answer 18

Aplasia cutis