Cvs

Question 1

Statins mechanism of action

Answer 1

Hypolipidaemic drugs
HMG-Coa reductase inhibition (competitive)(rate limiting step)
HMG COa —> Mevalonate

Decreases cholesterol synthesis

Decrease VLDL and LDL and triglycerides
increase HDL

Question 2

Prodrugs

Answer 2

Statins(hypolipidaemics)

Lovastatin,simvastatin

Question 3

ADR of statins

Answer 3

Hepatotoxicity
Increase transaminase levels
Myopathy
Rhabdomyolysis
Increase creatinine kinase
Git
Headache 
Sleep disorders

Question 4

Most potent statin

Answer 4

Pitavastatin

Question 5

Statin + cyclosporin
Statin + erythromycin
Statin + azoles

Answer 5

Inhibit statin metabolism

Increase myopathy

Question 6

Statins + fibrates

Answer 6

Increase rhabdomyolysis (myositis)
Decrease triglycerides
Decrease cholesterol

Question 7

Fibrates + bile resins

Answer 7

Cholesterol Gallstones

Question 8

Moa of fibrates hypolipidaemic

Answer 8

Activates PPAR-alpha
(Peroxisome proliferating-activated receptor alpha)

inhibits triglyceride synthesis

Question 9

Moa of bile acid binding resins(hypolipidaemics)

Answer 9

Bind bile acids
Decreased absorption of bile from intestine
Cholesterol —> bile acids

Increase hepatic LDL receptors

Question 10

Moa of niacin(hypolipidaemics)

Answer 10

Inhibits lipolysis

Increases lipoprotien lipase activity

Question 11

ADR of niacin

Answer 11

Flushing
Pruritis
Dysepsia
Peptic ulcer
Hyperuricemia
Hyperglycemia
Atrial arrhythmia

Question 12

Ezetimibe + statin

Answer 12

Synergistic

Decreased cholesterol absorption and synthesis

Question 13

Hydralazine + nitrates

Answer 13

Chronic heart failure

Question 14

Drug categories used for angina

Answer 14

Nitrates (nitroglycerin)
Beta blockers (propranolol)
Ca2+ channel blockers (Verapamil)
K+ channel openers (nicorandil)
Others

Question 15

Hypolipidemic drugs used

Answer 15

HMG-Coa reductase inhibitors/Statins
Fibrates/lipoprotien lipase activators
Bile acid sequestrants
Triglyceride synthesis inhibitors
Sterol absorption inhibitors

Question 16

Ankle edema is seen in which antianginal drug

Answer 16

Amlodipine(CCB)

Question 17

Which CCB crosses BBB and sdlectively dilated the cerebral blood vessels

Answer 17

Nimodipine

Tt of
cerebral vasospasms
Subarachnoid haemorrhage

Question 18

Drug categories used as antihypertensives

Answer 18

Diuretics(furosemide)
Ace inhibitors(captopril)
Angiotensin receptor blockers(ARB)(losartan)
Direct renin inhibitor (aliskiren)
Beta blockers(propranolol)
Alpha blockers(prazosin)
Central sympatho ( clonidine, methyldopa)

Question 19

Moa of ACE inhibitors

Answer 19

Arterial dilatation
Decreased sympathetic activity
Decreased Na+ H2O retention

Question 20

ACE inhibitors + K+ sparing diuretics

Answer 20

Hyperkalemia

Question 21

ACE inhibitors + lithium

Answer 21

Lithium Toxicity

Question 22

ACE inhibitors + NSAIDs

Answer 22

PG synthesis

Na+- H2O retention

Question 23

Thiazides + ACE inhibitors

Answer 23

Na+ levels maintained

Question 24

Tt of Hypertension + Diabetes

Answer 24

ACE inhibitors

Question 25

Reserpine MoA antihypertensive

Answer 25

Inhibit catecholamines release

Usage of monoamine oxidase

Question 26

Hypertensive drug tt depends on factors such as

Answer 26

Comorbidity
Associated complications
Age
Sex
Cost
Concomitant drugs

Question 27

Drug used in hypertensive emergency

Answer 27

Sodium nitroprusside

Question 28

Tt of angina + MI

Answer 28

Beta blockers

Question 29

Drug induced SLE is seen in

Answer 29

Hydralazine(atrial dilator)

Isoniazid