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Biochem > TCA, B-oxidation, oxidative phosphorylation > Flashcards

TCA, B-oxidation, oxidative phosphorylation Flashcards

1
Q

TCA cycle rxn 1 type

A

C-C bond formation by claisen condensation

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2
Q

TCA cycle rxn 1 enzyme

A

citrate synthase

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3
Q

TCA cycle rxn 1

A

acetyl-coA + oxaloacetate = citrate

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4
Q

TCA cycle rxn 2 type

A

isomerization

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5
Q

TCA cycle rxn 2 enzyme

A

aconitase

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6
Q

TCA cycle rxn 2

A

citrate to isocitrate
(cis-aconitase intermediate)

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7
Q

TCA cycle rxn 2 reason

A

citrate is a poor substrate for oxidation
isocitrate has secondary -OH which can be oxidized

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8
Q

citrate chirality

A

prochiral: aconitase removes pro-R H of pro-R arm

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9
Q

TCA cycle rxn 3 type

A

oxidative decarboxylation

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10
Q

TCA cycle rxn 3 enzyme

A

isocitrate dehydrogenase
- link to e- transport chain

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11
Q

TCA cycle rxn 3

A

isocitrate to a-ketoglutarate

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12
Q

TCA cycle rxn 3 intermediate

A

oxalosuccinate

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13
Q

TCA cycle rxn 4 type

A

oxidative decarboxylation

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14
Q

TCA cycle rxn 4 enzyme

A

a-ketoglutarate dehydrogenase
- complex

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15
Q

TCA cycle rxn 4

A

a-ketoglutarate to succinyl-coA

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16
Q

TCA cycle rxn 5 type

A

substrate-level phosphorylation

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17
Q

TCA cycle rxn 5 enzyme

A

succinyl-coA synthetase

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18
Q

TCA cycle rxn 5

A

succinyl-coA to succinate
- synthesis is driven by hydrolysis of coA ester

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19
Q

TCA cycle rxn 5 product type

A

nucleoside triphosphate

20
Q

TCA cycle rxn 6 type

A

oxidation involving FAD

21
Q

TCA cycle rxn 6 enzyme

A

succinate dehydrogenase

22
Q

TCA cycle rxn 6

A

succinate to fumarate

23
Q

TCA cycle rxn 6 FAD

A

FAD to FADH2
part of e- transport chain

24
Q

TCA cycle rxn 7 type

A

hydration across double bond

25
Q

TCA cycle rxn 7 enzyme

26
Q

TCA cycle rxn 7

A

fumarate to L-malate
- carbanion transition state

27
Q

TCA cycle rxn 8 type

A

carbon oxidation

28
Q

TCA cycle rxn 8 enzyme

A

malate dehydrogenase

29
Q

TCA cycle rxn 8

A

L-malate to oxaloacetate

30
Q

TCA cycle rxn 8: NAD+

A

NAD+ to NADH + H+

31
Q

B-oxidation step 1 type

A

oxidation of Ca-Cb bond

32
Q

B-oxidation step 1 enzyme

A

acyl-coA dehydrogenase

33
Q

B-oxidation step 1 hydride removal

34
Q

B-oxidation step 1 rxn

A

Palmitoyl-coA to trans-delta-Enoyl-coA

35
Q

B-oxidation step 2 type

A

water added across double bond

36
Q

B-oxidation step 2 enzyme

A

enoyl-coA hydratase

37
Q

B-oxidation step 2 rxn

A

trans-delta-enoyl-coA to L-B-hydroxyacyl-coA

38
Q

B-oxidation step 3 type

A

oxidation of B-hydroxyl group

39
Q

B-oxidation step 3 enzyme

A

hydroxyacyl-coA dehydrogenase

40
Q

B-oxidation step 3 cofactor

41
Q

B-oxidation step 3 rxn

A

L-B-hydroxyacyl-coA to B-ketoacyl-coA

42
Q

B-oxidation step 4 type

A

thiolase/reverse claisen condensation

43
Q

B-oxidation step 4 enzyme

44
Q

B-oxidation step 4 rxn

A

B-ketoacyl-coA to acyl coA and acetyl-coA

45
Q

hormone regulation: epinephrine

A

need energy

46
Q

hormone regulation: glucagon

A

need glucose

47
Q

ketone body formation

A

lack of oxaloacetate
acetyl-coA converted into ketone bodies

Biochem (8 decks)

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