TBL Module 7-9 Questions Flashcards
Which 2 conditions forms “onion bulb” appearance of layers of Schwann cells around the axon?
1) Charcot- Marie Tooth disease
2) Chronic inflammatory demyelinating polyneuropathy
Which condition is associated with ascending paralysis?
A) MS
B) CMT2
C) chronic inflammatory demylienating polyneuropathy
D) Guillain Barre
D) Guillain Barre
All of these conditions are categorized as an autoimmune disorder EXCEPT:
A) Guillain Barre
B) Charcot-Marie Tooth disease
C) MS
D) chronic inflammatory demyelinating polyneuropathy
B) Charcot-Marie Tooth disease
Which sign is associated with Charcot-Marie Tooth disease?
inverted champagne bottle shaped legs
Which demyelinating disorder is associated with unilateral visual impairment?
MS
Guillain Barre syndrome begins with ________________ weakness that progresses toward the trunk
distal extremity
What is the most common type of CMT?
CMT1
CMT1 causes demyelination because Schwann cells unravel due to….
mutation of myelin protein zero
Guillain Barre syndrome is often preceded by a….
microorganismal infection
Which condition is associated with abnormal production of axonal mitochondria?
CMT 2
T cell target myelin cells in these conditions except:
A) MS
B) Guillain Barre
C) chronic demyelinating polyradiculopathy
D) charcot-marie tooth disease
D) charcot-marie tooth disease
Which condition shows the histopathological finding of widespread inflammation and demyelination of peripheral spinal nerve roots?
Guillain Barre
What is the pathogenesis of CMT disease?
mutation of myelin protein zero
How does myasthenia gravis affect the NMJ?
damages ACh receptors
What effect does botulism toxin have at the NMJ?
prevents the release of ACh
Is this myasthenia gravis, multiple sclerosis, or both?
-muscle weakness
both
Is this myasthenia gravis, multiple sclerosis, or both?
-can effect vision
both
Is this myasthenia gravis, multiple sclerosis, or both?
-ptosis
MG
Is this myasthenia gravis, multiple sclerosis, or both?
-effects speech
MG
Is this myasthenia gravis, multiple sclerosis, or both?
-can have periods of remission
both
Is this myasthenia gravis, multiple sclerosis, or both?
-demyelination
MS
Is this myasthenia gravis, multiple sclerosis, or both?
-responds to cholinesterase inhibitor drugs
MG
Is this myasthenia gravis, multiple sclerosis, or both?
-autoimmune disorder
both
Is this myasthenia gravis, multiple sclerosis, or both?
-difficulty swallowing
MG
Is this myasthenia gravis, multiple sclerosis, or both?
-sensitive to temp (hot or cold)
MS
Spores germinate in a __________________________ environment
moist anaerobic alkaline to low acidic
Why should you NOT give honey to babies?
it contains spores
What is the progression of botulism signs and symptoms?
begins with bilateral muscle weakness that leads to paralysis of the face, neck, arms, trunk, and legs
The unilateral visual impairment clinical feature associated with MS is due to demyelination of the __________
optic nerve
T/F: MG affects both sensory and motor neurons
false
Abnormal function of this organ has been associated with MG
thymus
Which phase of the C. botulinum bacteria’s life cycle does it produce toxins?
when spores are germinating
How does botulinum toxin enter a neuron?
endocytosis
Which SNARE is damaged by botulism toxin?
synaptobrevin
How does damage to a vSNARE affect a neuron’s function?
a vesicle cannot fuse to the presynaptic membrane
Botulism toxin poisoning is not fatal if treated in time before it affects the _____________ system
respiratory
Which condition affects all neural crest origin cells?
neurofibromatosis
Which condition is caused by the ingestion of infected meat?
variant CJD
Fatal Familial Insomnia causes damage to the….
thalamus
What are prions?
abnormally folded proteins
Which disease has a halo spongiform appearance of brain tissue?
variant CJD
Which disease has spongiform appearance of the cerebral cortex and basal ganglia?
CJD (sporadic or iatrogenic)
Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-problems with balance
meniere’s disease and NF2
Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-cafe au lait spots/melanocytic hemartomas
NF1
Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-ataxia
fatal familial insomnia
Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-lisch nodules
NF1
Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-hearing loss
NF2 and meniere’s disease
Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-aural fullness
meniere’s disease
Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-vestibular schwannoma
NF2
Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-cutaneous neurofibromas
NF1
Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-tinnitus
NF2 and meniere’s disease
Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-scoliosis
NF1
