TBL Module 7-9 Questions

Question 1

Which 2 conditions forms “onion bulb” appearance of layers of Schwann cells around the axon?

Answer 1

1) Charcot- Marie Tooth disease
2) Chronic inflammatory demyelinating polyneuropathy

Question 2

Which condition is associated with ascending paralysis?
A) MS
B) CMT2
C) chronic inflammatory demylienating polyneuropathy
D) Guillain Barre

Answer 2

D) Guillain Barre

Question 3

All of these conditions are categorized as an autoimmune disorder EXCEPT:
A) Guillain Barre
B) Charcot-Marie Tooth disease
C) MS
D) chronic inflammatory demyelinating polyneuropathy

Answer 3

B) Charcot-Marie Tooth disease

Question 4

Which sign is associated with Charcot-Marie Tooth disease?

Answer 4

inverted champagne bottle shaped legs

Question 5

Which demyelinating disorder is associated with unilateral visual impairment?

Answer 5

MS

Question 6

Guillain Barre syndrome begins with ________________ weakness that progresses toward the trunk

Answer 6

distal extremity

Question 7

What is the most common type of CMT?

Answer 7

CMT1

Question 8

CMT1 causes demyelination because Schwann cells unravel due to….

Answer 8

mutation of myelin protein zero

Question 9

Guillain Barre syndrome is often preceded by a….

Answer 9

microorganismal infection

Question 10

Which condition is associated with abnormal production of axonal mitochondria?

Answer 10

CMT 2

Question 11

T cell target myelin cells in these conditions except:
A) MS
B) Guillain Barre
C) chronic demyelinating polyradiculopathy
D) charcot-marie tooth disease

Answer 11

D) charcot-marie tooth disease

Question 12

Which condition shows the histopathological finding of widespread inflammation and demyelination of peripheral spinal nerve roots?

Answer 12

Guillain Barre

Question 13

What is the pathogenesis of CMT disease?

Answer 13

mutation of myelin protein zero

Question 14

How does myasthenia gravis affect the NMJ?

Answer 14

damages ACh receptors

Question 15

What effect does botulism toxin have at the NMJ?

Answer 15

prevents the release of ACh

Question 16

Is this myasthenia gravis, multiple sclerosis, or both?
-muscle weakness

Answer 16

both

Question 17

Is this myasthenia gravis, multiple sclerosis, or both?
-can effect vision

Answer 17

both

Question 18

Is this myasthenia gravis, multiple sclerosis, or both?
-ptosis

Answer 18

MG

Question 19

Is this myasthenia gravis, multiple sclerosis, or both?
-effects speech

Answer 19

MG

Question 20

Is this myasthenia gravis, multiple sclerosis, or both?
-can have periods of remission

Answer 20

both

Question 21

Is this myasthenia gravis, multiple sclerosis, or both?
-demyelination

Answer 21

MS

Question 22

Is this myasthenia gravis, multiple sclerosis, or both?
-responds to cholinesterase inhibitor drugs

Answer 22

MG

Question 23

Is this myasthenia gravis, multiple sclerosis, or both?
-autoimmune disorder

Answer 23

both

Question 24

Is this myasthenia gravis, multiple sclerosis, or both?
-difficulty swallowing

Answer 24

MG

Question 25

Is this myasthenia gravis, multiple sclerosis, or both? -sensitive to temp (hot or cold)

Answer 25

MS

Question 26

Spores germinate in a __________________________ environment

Answer 26

moist anaerobic alkaline to low acidic

Question 27

Why should you NOT give honey to babies?

Answer 27

it contains spores

Question 28

What is the progression of botulism signs and symptoms?

Answer 28

begins with bilateral muscle weakness that leads to paralysis of the face, neck, arms, trunk, and legs

Question 29

The unilateral visual impairment clinical feature associated with MS is due to demyelination of the __________

Answer 29

optic nerve

Question 30

T/F: MG affects both sensory and motor neurons

Answer 30

false

Question 31

Abnormal function of this organ has been associated with MG

Answer 31

thymus

Question 32

Which phase of the C. botulinum bacteria's life cycle does it produce toxins?

Answer 32

when spores are germinating

Question 33

How does botulinum toxin enter a neuron?

Answer 33

endocytosis

Question 34

Which SNARE is damaged by botulism toxin?

Answer 34

synaptobrevin

Question 35

How does damage to a vSNARE affect a neuron's function?

Answer 35

a vesicle cannot fuse to the presynaptic membrane

Question 36

Botulism toxin poisoning is not fatal if treated in time before it affects the _____________ system

Answer 36

respiratory

Question 37

Which condition affects all neural crest origin cells?

Answer 37

neurofibromatosis

Question 38

Which condition is caused by the ingestion of infected meat?

Answer 38

variant CJD

Question 39

Fatal Familial Insomnia causes damage to the....

Answer 39

thalamus

Question 40

What are prions?

Answer 40

abnormally folded proteins

Question 41

Which disease has a halo spongiform appearance of brain tissue?

Answer 41

variant CJD

Question 42

Which disease has spongiform appearance of the cerebral cortex and basal ganglia?

Answer 42

CJD (sporadic or iatrogenic)

Question 43

Is this NF1, NF2, meniere''s, or fatal familial insomnia? -problems with balance

Answer 43

meniere's disease and NF2

Question 44

Is this NF1, NF2, meniere''s, or fatal familial insomnia? -cafe au lait spots/melanocytic hemartomas

Answer 44

NF1

Question 45

Is this NF1, NF2, meniere''s, or fatal familial insomnia? -ataxia

Answer 45

fatal familial insomnia

Question 46

Is this NF1, NF2, meniere''s, or fatal familial insomnia? -lisch nodules

Answer 46

NF1

Question 47

Is this NF1, NF2, meniere''s, or fatal familial insomnia? -hearing loss

Answer 47

NF2 and meniere's disease

Question 48

Is this NF1, NF2, meniere''s, or fatal familial insomnia? -aural fullness

Answer 48

meniere's disease

Question 49

Is this NF1, NF2, meniere''s, or fatal familial insomnia? -vestibular schwannoma

Answer 49

NF2

Question 50

Is this NF1, NF2, meniere''s, or fatal familial insomnia? -cutaneous neurofibromas

Answer 50

NF1

Question 51

Is this NF1, NF2, meniere''s, or fatal familial insomnia? -tinnitus

Answer 51

NF2 and meniere's disease

Question 52

Is this NF1, NF2, meniere''s, or fatal familial insomnia? -scoliosis

Answer 52

NF1