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Neuropathophysiology > TBL Module 7-9 Questions > Flashcards

TBL Module 7-9 Questions Flashcards

1
Q

Which 2 conditions forms “onion bulb” appearance of layers of Schwann cells around the axon?

A

1) Charcot- Marie Tooth disease
2) Chronic inflammatory demyelinating polyneuropathy

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2
Q

Which condition is associated with ascending paralysis?
A) MS
B) CMT2
C) chronic inflammatory demylienating polyneuropathy
D) Guillain Barre

A

D) Guillain Barre

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3
Q

All of these conditions are categorized as an autoimmune disorder EXCEPT:
A) Guillain Barre
B) Charcot-Marie Tooth disease
C) MS
D) chronic inflammatory demyelinating polyneuropathy

A

B) Charcot-Marie Tooth disease

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4
Q

Which sign is associated with Charcot-Marie Tooth disease?

A

inverted champagne bottle shaped legs

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5
Q

Which demyelinating disorder is associated with unilateral visual impairment?

A

MS

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6
Q

Guillain Barre syndrome begins with ________________ weakness that progresses toward the trunk

A

distal extremity

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7
Q

What is the most common type of CMT?

A

CMT1

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8
Q

CMT1 causes demyelination because Schwann cells unravel due to….

A

mutation of myelin protein zero

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9
Q

Guillain Barre syndrome is often preceded by a….

A

microorganismal infection

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10
Q

Which condition is associated with abnormal production of axonal mitochondria?

A

CMT 2

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11
Q

T cell target myelin cells in these conditions except:
A) MS
B) Guillain Barre
C) chronic demyelinating polyradiculopathy
D) charcot-marie tooth disease

A

D) charcot-marie tooth disease

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12
Q

Which condition shows the histopathological finding of widespread inflammation and demyelination of peripheral spinal nerve roots?

A

Guillain Barre

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13
Q

What is the pathogenesis of CMT disease?

A

mutation of myelin protein zero

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14
Q

How does myasthenia gravis affect the NMJ?

A

damages ACh receptors

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15
Q

What effect does botulism toxin have at the NMJ?

A

prevents the release of ACh

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16
Q

Is this myasthenia gravis, multiple sclerosis, or both?
-muscle weakness

A

both

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17
Q

Is this myasthenia gravis, multiple sclerosis, or both?
-can effect vision

A

both

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18
Q

Is this myasthenia gravis, multiple sclerosis, or both?
-ptosis

A

MG

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19
Q

Is this myasthenia gravis, multiple sclerosis, or both?
-effects speech

A

MG

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20
Q

Is this myasthenia gravis, multiple sclerosis, or both?
-can have periods of remission

A

both

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21
Q

Is this myasthenia gravis, multiple sclerosis, or both?
-demyelination

A

MS

22
Q

Is this myasthenia gravis, multiple sclerosis, or both?
-responds to cholinesterase inhibitor drugs

A

MG

23
Q

Is this myasthenia gravis, multiple sclerosis, or both?
-autoimmune disorder

A

both

24
Q

Is this myasthenia gravis, multiple sclerosis, or both?
-difficulty swallowing

A

MG

25
Q

Is this myasthenia gravis, multiple sclerosis, or both?
-sensitive to temp (hot or cold)

A

MS

26
Q

Spores germinate in a __________________________ environment

A

moist anaerobic alkaline to low acidic

27
Q

Why should you NOT give honey to babies?

A

it contains spores

28
Q

What is the progression of botulism signs and symptoms?

A

begins with bilateral muscle weakness that leads to paralysis of the face, neck, arms, trunk, and legs

29
Q

The unilateral visual impairment clinical feature associated with MS is due to demyelination of the __________

A

optic nerve

30
Q

T/F: MG affects both sensory and motor neurons

A

false

31
Q

Abnormal function of this organ has been associated with MG

A

thymus

32
Q

Which phase of the C. botulinum bacteria’s life cycle does it produce toxins?

A

when spores are germinating

33
Q

How does botulinum toxin enter a neuron?

A

endocytosis

34
Q

Which SNARE is damaged by botulism toxin?

A

synaptobrevin

35
Q

How does damage to a vSNARE affect a neuron’s function?

A

a vesicle cannot fuse to the presynaptic membrane

36
Q

Botulism toxin poisoning is not fatal if treated in time before it affects the _____________ system

A

respiratory

37
Q

Which condition affects all neural crest origin cells?

A

neurofibromatosis

38
Q

Which condition is caused by the ingestion of infected meat?

A

variant CJD

39
Q

Fatal Familial Insomnia causes damage to the….

A

thalamus

40
Q

What are prions?

A

abnormally folded proteins

41
Q

Which disease has a halo spongiform appearance of brain tissue?

A

variant CJD

42
Q

Which disease has spongiform appearance of the cerebral cortex and basal ganglia?

A

CJD (sporadic or iatrogenic)

43
Q

Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-problems with balance

A

meniere’s disease and NF2

44
Q

Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-cafe au lait spots/melanocytic hemartomas

A

NF1

45
Q

Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-ataxia

A

fatal familial insomnia

46
Q

Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-lisch nodules

A

NF1

47
Q

Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-hearing loss

A

NF2 and meniere’s disease

48
Q

Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-aural fullness

A

meniere’s disease

49
Q

Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-vestibular schwannoma

A

NF2

50
Q

Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-cutaneous neurofibromas

A

NF1

51
Q

Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-tinnitus

A

NF2 and meniere’s disease

52
Q

Is this NF1, NF2, meniere’’s, or fatal familial insomnia?
-scoliosis

A

NF1

Neuropathophysiology (16 decks)

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